Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)

RAP1; DRIP5; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog

SPN	N628
HGNC	19246
MGI	1929871
PubMed	24316969
RGD	1309684
UniProt	Q9NYB0
Wiki	TERF2IP

The RAP1 cDNA is identical to the KAIA804 cDNA reported by the NEDO Japanese sequencing project. The predicted 47-kD RAP1 protein contains 399 amino acids. A motif search revealed that RAP1 has an N-terminal BRCT domain and a central Myb-type helix-turn-helix motif. RAP1 also has an acidic C terminus (amino acids 214 to 382; pI around 3.8) featuring a predicted 33-amino acid coiled-coil region and a bipartite nuclear localization signal. Sequence alignments showed an additional region of sequence similarity in the C termini of yeast and human RAP1 that coincides with the main protein-protein interaction domain of S. cerevisiae Rap1. Thus, human RAP1 has 3 conserved sequence motifs in common with yeast Rap1.Northern blot analysis detected ubiquitous expression of a 2.5-kb RAP1 transcript.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Hu01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Hu01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Hu01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Hu01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Hu01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Mu01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Mu01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Mu01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Mu01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Mu01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Ra01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Ra01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Ra01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Ra01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Ra01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Ca01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Ca01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Ca01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Ca01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Ca01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Po01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Po01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Po01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Po01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Po01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Bo01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Bo01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Bo01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Bo01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Bo01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Rb01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Rb01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Rb01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Rb01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Rb01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN628Mo01	Recombinant Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN628Mo01	Monoclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IP.
Antibodies	PAN628Mo01	Polyclonal Antibody to Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	WB; IHC; ICC; IF.
Assay Kits	CLN628Mo01	CLIA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	CLIA assay for Antigen Detection
Assay Kits	ELN628Mo01	ELISA Kit for Telomeric Repeat Binding Factor 2 Interacting Protein (TERF2IP)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of human RAP1: implications for telomere evolution."
Cell 101:471-483(2000) [PubMed] [Europe PMC] [Abstract]

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes."
Gene 323:1-10(2003) [PubMed] [Europe PMC] [Abstract]

"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."
J. Biol. Chem. 279:47264-47271(2004) [PubMed] [Europe PMC] [Abstract]

"Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."
J. Biol. Chem. 279:51338-51342(2004) [PubMed] [Europe PMC] [Abstract]

"Shelterin: the protein complex that shapes and safeguards human telomeres."
Genes Dev. 19:2100-2110(2005) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."
Cell 138:63-77(2009) [PubMed] [Europe PMC] [Abstract]

"Human RAP1 inhibits non-homologous end joining at telomeres."
EMBO J. 28:3390-3399(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains."
J. Mol. Biol. 312:167-175(2001) [PubMed] [Europe PMC] [Abstract]