Nucleotide Binding Oligomerization Domain Containing Protein 1 (NOD1)

CARD4; CLR7.1; NLRC1; Caspase Recruitment Domain Family,Member 4; Nucleotide-Binding Oligomerization Domain,Leucine Rich Repeat And CARD Domain Containing 1

SPN	N436
HGNC	16390
MGI	1341839
PubMed	23542589
RGD	1562269
UniProt	Q9Y239
Wiki	NOD1

NOD1 encodes a member of the NOD family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined.

Reference

"Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB."
J. Biol. Chem. 274:12955-12958(1999) [PubMed] [Europe PMC] [Abstract]

"Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB."
J. Biol. Chem. 274:14560-14567(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human Nod1 confers responsiveness to bacterial lipopolysaccharides."
J. Biol. Chem. 276:2551-2554(2001) [PubMed] [Europe PMC] [Abstract]

"The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction."
Cell. Microbiol. 10:477-486(2008) [PubMed] [Europe PMC] [Abstract]

"GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors."
PLoS Pathog. 4:E1000228-E1000228(2008) [PubMed] [Europe PMC] [Abstract]

"NLRP10 enhances Shigella-induced pro-inflammatory responses."
Cell. Microbiol. 14:1568-1583(2012) [PubMed] [Europe PMC] [Abstract]

"The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway."
Cell. Physiol. Biochem. 33:1954-1962(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the CARD domain in human caspase recruitment domain protein 4 (NOD1 protein)."
Submitted (DEC-2006) to the PDB data bank

"Crystal structure of the Nod1 caspase activation and recruitment domain."
Biochem. Biophys. Res. Commun. 353:1-5(2007) [PubMed] [Europe PMC] [Abstract]

"Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK."
J. Mol. Biol. 365:160-174(2007) [PubMed] [Europe PMC] [Abstract]

"Monomer/dimer transition of the caspase-recruitment domain of human Nod1."
Biochemistry 47:1319-1325(2008) [PubMed] [Europe PMC] [Abstract]