Sprouty Homolog 2 (SPRY2)

SPN	N379
HGNC	11270
MGI	1345138
PubMed	21278789
RGD	1311472
UniProt	O43597
Wiki	SPRY2

SPRY2 contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Hu01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Hu01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Hu01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Hu01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Hu01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Mu01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Mu01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Mu01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Mu01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Mu01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Ra01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Ra01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Ra01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Ra01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Ra01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Ca01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Ca01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Ca01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Ca01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Ca01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Po01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Po01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Po01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Po01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Po01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Bo01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Bo01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Bo01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Bo01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Bo01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Rb01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Rb01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Rb01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Rb01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Rb01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPN379Mo01	Recombinant Sprouty Homolog 2 (SPRY2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAN379Mo01	Monoclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IP.
Antibodies	PAN379Mo01	Polyclonal Antibody to Sprouty Homolog 2 (SPRY2)	WB; IHC; ICC; IF.
Assay Kits	CLN379Mo01	CLIA Kit for Sprouty Homolog 2 (SPRY2)	CLIA assay for Antigen Detection
Assay Kits	ELN379Mo01	ELISA Kit for Sprouty Homolog 2 (SPRY2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain."
J. Biol. Chem. 275:32837-32845(2000) [PubMed] [Europe PMC] [Abstract]

"Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1."
Nat. Cell Biol. 5:427-432(2003) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate."
J. Biochem. 149:685-692(2011) [PubMed] [Europe PMC] [Abstract]