AXL Receptor Tyrosine Kinase (AXL)

UFO; JTK11; Tyrosine-protein kinase receptor UFO

SPN	N159
HGNC	905
MGI	1347244
PubMed	23649974
RGD	620028
UniProt	P30530
Wiki	AXL

AXL is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduce signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.

Reference

"Putative tyrosine kinases expressed in K-562 human leukemia cells."
Proc. Natl. Acad. Sci. U.S.A. 87:8913-8917(1990) [PubMed] [Europe PMC] [Abstract]

"AXL, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase."
Mol. Cell. Biol. 11:5016-5031(1991) [PubMed] [Europe PMC] [Abstract]

"A novel putative tyrosine kinase receptor with oncogenic potential."
Oncogene 6:2113-2120(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes."
Oncogene 8:3403-3410(1993) [PubMed] [Europe PMC] [Abstract]

"Receptor tyrosine kinases expressed in metastatic colon cancer."
Int. J. Cancer 60:791-797(1995) [PubMed] [Europe PMC] [Abstract]

"Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6."
Nature 373:623-626(1995) [PubMed] [Europe PMC] [Abstract]

"Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl."
J. Biol. Chem. 271:9785-9789(1996) [PubMed] [Europe PMC] [Abstract]

"Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site."
Oncogene 14:2619-2631(1997) [PubMed] [Europe PMC] [Abstract]

"A receptor tyrosine kinase, UFO/Axl, and other genes isolated by a modified differential display PCR are overexpressed in metastatic prostatic carcinoma cell line DU145."
Cancer Detect. Prev. 23:325-332(1999) [PubMed] [Europe PMC] [Abstract]

"Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast."
Ann. Oncol. 12:819-824(2001) [PubMed] [Europe PMC] [Abstract]

"Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]

"Acidification prevents endothelial cell apoptosis by Axl activation."
Circ. Res. 91:E4-12(2002) [PubMed] [Europe PMC] [Abstract]

"Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around Chernobyl."
Thyroid 12:971-975(2002) [PubMed] [Europe PMC] [Abstract]

"Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation."
Biochem. Biophys. Res. Commun. 333:180-185(2005) [PubMed] [Europe PMC] [Abstract]

"Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor."
Blood 105:1970-1976(2005) [PubMed] [Europe PMC] [Abstract]

"Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses."
J. Thromb. Haemost. 3:733-741(2005) [PubMed] [Europe PMC] [Abstract]

"Tyro3 family-mediated cell entry of Ebola and Marburg viruses."
J. Virol. 80:10109-10116(2006) [PubMed] [Europe PMC] [Abstract]

"In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation."
J. Neurochem. 106:134-146(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development."
Blood 113:2470-2477(2009) [PubMed] [Europe PMC] [Abstract]

"Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling."
J. Biol. Chem. 284:34954-34963(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis for Gas6-Axl signalling."
EMBO J. 25:80-87(2006) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]