DEAD Box Polypeptide 5 (DDX5)

G17P1; HLR1; HELR; HUMP68; p68; Asp-Glu-Ala-Asp Box Polypeptide 5; Probable ATP-dependent RNA helicase DDX5

SPN	M968
HGNC	2746
MGI	105037
PubMed	17960593
RGD	619906
UniProt	P17844
Wiki	DDX5

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.

DDX5 encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen.DDX5 consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.

Reference

"Complete cDNA sequence of the human p68 protein."
Nucleic Acids Res. 18:3045-3045(1990) [PubMed] [Europe PMC] [Abstract]

"p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts."
Mol. Cell. Biol. 11:1326-1333(1991) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of the human p68 RNA helicase gene."
Nucleic Acids Res. 28:932-939(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Nuclear protein with sequence homology to translation initiation factor eIF-4A."
Nature 332:736-738(1988) [PubMed] [Europe PMC] [Abstract]

"Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha."
Mol. Cell. Biol. 19:5363-5372(1999) [PubMed] [Europe PMC] [Abstract]

"The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase."
Exp. Cell Res. 257:272-280(2000) [PubMed] [Europe PMC] [Abstract]

"A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA."
EMBO J. 20:1341-1352(2001) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]

"The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells."
Nucleic Acids Res. 31:1470-1480(2003) [PubMed] [Europe PMC] [Abstract]

"Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300."
Oncogene 22:151-156(2003) [PubMed] [Europe PMC] [Abstract]

"The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner."
BMC Mol. Biol. 5:11-11(2004) [PubMed] [Europe PMC] [Abstract]

"The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor."
EMBO J. 24:543-553(2005) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation."
Dev. Cell 11:547-560(2006) [PubMed] [Europe PMC] [Abstract]

"Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]

"SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1."
Oncogene 26:5866-5876(2007) [PubMed] [Europe PMC] [Abstract]

"The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer."
Cancer Res. 68:7938-7946(2008) [PubMed] [Europe PMC] [Abstract]

"p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation."
J. Cell. Biochem. 103:1438-1451(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer."
Oncogene 28:4053-4064(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential."
Biochemistry 49:1-10(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site."
Mol. Cell. Biol. 31:1812-1821(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative structural analysis of human DEAD-box RNA helicases."
PLoS ONE 5:E12791-E12791(2010) [PubMed] [Europe PMC] [Abstract]