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Mindbomb Homolog 2 (MIB2)

ZZANK1; SKD; ZZZ5; Skeletrophin; Novelzin; Novel zinc finger protein; Zinc Finger,ZZ Type With Ankyrin Repeat Domain 1; Putative NF-kappa-B-activating protein; Mind bomb 2

Skeletrophin was expressed in 23 of 25 benign nevi, but not in 18 of 38 cases of primary skin melanoma. Treatment with a demethylating agent restored skeletrophin expression in a human melanoma cell line.The deduced 1,013-amino acid protein contains a dystrophin (DMD)-like cysteine-rich zinc-binding domain in its N-terminal half and 5 ankyrin repeats in its C-terminal half. Northern blot analysis detected a 3.2-kb transcript that was highly expressed in skeletal muscle and more weakly expressed in brain, heart, and kidney. Western blot analysis detected a 70-kD protein in skeletal muscle, heart, and brain, but not in liver, thymus, or lung. Immunohistochemical analysis of skeletal muscle detected cytoplasmic foci of skeletrophin expression near the cell surface.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Hu01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Hu01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Hu01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Hu01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Hu01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Mu01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Mu01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Mu01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Mu01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Mu01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Ra01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Ra01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Ra01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Ra01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Ra01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Ca01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Ca01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Ca01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Ca01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Ca01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Po01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Po01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Po01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Po01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Po01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Bo01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Bo01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Bo01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Bo01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Bo01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Rb01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Rb01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Rb01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Rb01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Rb01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPM666Mo01 Recombinant Mindbomb Homolog 2 (MIB2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAM666Mo01 Monoclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IP.
PAM666Mo01 Polyclonal Antibody to Mindbomb Homolog 2 (MIB2) WB; IHC; ICC; IF.
Assay Kits CLM666Mo01 CLIA Kit for Mindbomb Homolog 2 (MIB2) CLIA assay for Antigen Detection
ELM666Mo01 ELISA Kit for Mindbomb Homolog 2 (MIB2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma."
Am. J. Pathol. 163:1395-1404(2003) [PubMed] [Europe PMC] [Abstract]

"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]