Src Homology 2 Domain Containing Adapter Protein B (SHB)

SH2 Domain Containing Adapter Protein B

SPN	M176
HGNC	10838
MGI	98294
PubMed	19696098
UniProt	Q15464
Wiki	SHB

Many proteins involved in the regulation of cellular proliferation contain sequence motifs named SH2 and SH3 . These domains mediate interaction with other proteins; the SH2 domain interacts with tyrosine phosphorylation sites, while SH3 domains interact with proline-rich sequences. Many signal transduction pathways involve the induction of the formation of complexes of proteins such as growth factor receptors, adaptor proteins, and target enzymes through SH2 and SH3 interactions. Adaptor proteins are molecules with multiple protein interaction motifs that do not appear to have catalytic activity of their own but mediate the interaction of other proteins. The SHB gene encodes 2 such adaptor proteins (from 2 different start methionines) of 67 and 56 kD .

Reference

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"The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells."
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"Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins."
Oncogene 16:891-901(1998) [PubMed] [Europe PMC] [Abstract]

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"Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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