Histone Cluster 1, H2aa (HIST1H2AA)

H2AFR; H2A Histone Family Member R

SPN	L247
HGNC	18729
MGI	2448285
PubMed	12408966
RGD	3854
UniProt	Q96QV6
Wiki	HIST1H2AA

The HIST1H2AA gene is the most telomeric H2A gene within the HIST1 cluster. The HIST1 cluster spans over 2 Mb and includes 2 large gaps (over 250 kb each) where there are no histone genes, but many other genes. The organization of histone genes in the mouse Hist1 cluster on chromosome 13A2-A3 is essentially identical to that in human HIST1. The HIST2 cluster on chromosome 1q21 contains 6 histone genes, including 3 H2A genes, and the HIST3 cluster on chromosome 1q42 contains 3 histone genes, including 1 H2A gene (HIST3H2A). Hist2 and Hist3 are located on mouse chromosomes 3F1-F2 and 11B2, respectively. These paired H2A and H2B genes are transcribed from opposite strands, with their 5-prime ends separated by an intergenic region of less than 300 nucleotides.

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