Checkpoint Kinase 2 (CHEK2)
RAD53; CDS1; CHK2; HuCds1; Serine/threonine-protein kinase Chk2
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Hu01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Hu01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Hu01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Hu01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Hu01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Mu01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Mu01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Mu01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Mu01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Mu01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Ra01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Ra01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Ra01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Ra01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Ra01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Ca01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Ca01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Ca01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Ca01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Ca01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Po01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Po01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Po01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Po01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Po01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Bo01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Bo01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Bo01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Bo01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Bo01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Rb01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Rb01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Rb01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Rb01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Rb01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPK968Mo01 | Recombinant Checkpoint Kinase 2 (CHEK2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAK968Mo01 | Monoclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IP. |
| PAK968Mo01 | Polyclonal Antibody to Checkpoint Kinase 2 (CHEK2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLK968Mo01 | CLIA Kit for Checkpoint Kinase 2 (CHEK2) | CLIA assay for Antigen Detection |
| ELK968Mo01 | ELISA Kit for Checkpoint Kinase 2 (CHEK2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Linkage of ATM to cell cycle regulation by the Chk2 protein kinase."
Science 282:1893-1897(1998) [PubMed] [Europe PMC] [Abstract]
"A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase."
Curr. Biol. 9:1-10(1999) [PubMed] [Europe PMC] [Abstract]
"A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage."
Proc. Natl. Acad. Sci. U.S.A. 96:3745-3750(1999) [PubMed] [Europe PMC] [Abstract]
"Alternative splicing and mutation status of CHEK2 in stage III breast cancer."
Oncogene 23:8535-8544(2004) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response."
Nature 404:201-204(2000) [PubMed] [Europe PMC] [Abstract]
"Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro."
Proc. Natl. Acad. Sci. U.S.A. 97:10389-10394(2000) [PubMed] [Europe PMC] [Abstract]
"The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation."
J. Biol. Chem. 276:30537-30541(2001) [PubMed] [Europe PMC] [Abstract]
"The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis."
Nature 410:842-847(2001) [PubMed] [Europe PMC] [Abstract]
"A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer."
Am. J. Hum. Genet. 71:432-438(2002) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain."
J. Biol. Chem. 277:19389-19395(2002) [PubMed] [Europe PMC] [Abstract]
"PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2."
Nat. Cell Biol. 4:865-870(2002) [PubMed] [Europe PMC] [Abstract]
"53BP1, a mediator of the DNA damage checkpoint."
Science 298:1435-1438(2002) [PubMed] [Europe PMC] [Abstract]
"The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation."
J. Biol. Chem. 278:33134-33141(2003) [PubMed] [Europe PMC] [Abstract]
"Chk2 activates E2F-1 in response to DNA damage."
Nat. Cell Biol. 5:401-409(2003) [PubMed] [Europe PMC] [Abstract]
"MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways."
Nature 421:957-961(2003) [PubMed] [Europe PMC] [Abstract]
"The Chk2 protein kinase."
DNA Repair 3:1039-1047(2004) [PubMed] [Europe PMC] [Abstract]
"The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway."
J. Biol. Chem. 279:47652-47660(2004) [PubMed] [Europe PMC] [Abstract]
"ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage."
EMBO J. 24:3411-3422(2005) [PubMed] [Europe PMC] [Abstract]
"Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase."
Cell Death Differ. 13:1170-1180(2006) [PubMed] [Europe PMC] [Abstract]
"Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage."
Mutat. Res. 596:166-176(2006) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage."
EMBO J. 26:2083-2093(2007) [PubMed] [Europe PMC] [Abstract]
"Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456."
J. Biol. Chem. 282:30311-30321(2007) [PubMed] [Europe PMC] [Abstract]
"Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."
Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]
"Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation."
Cell Cycle 7:2705-2709(2008) [PubMed] [Europe PMC] [Abstract]
"Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379."
Mol. Cell. Biol. 28:5874-5885(2008) [PubMed] [Europe PMC] [Abstract]
"The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage."
Oncogene 27:3977-3985(2008) [PubMed] [Europe PMC] [Abstract]
"Polo-like kinase 4 phosphorylates Chk2."
Cell Cycle 8:327-329(2009) [PubMed] [Europe PMC] [Abstract]
"The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells."
Nat. Cell Biol. 12:492-499(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"A recurrent CHEK2 p.H371Y mutation is associated with breast cancer risk in Chinese women."
Hum. Mutat. 32:1000-1003(2011) [PubMed] [Europe PMC] [Abstract]
"The E3 ligase RNF8 regulates KU80 removal and NHEJ repair."
Nat. Struct. Mol. Biol. 19:201-206(2012) [PubMed] [Europe PMC] [Abstract]
"Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2."
Mol. Cell 9:1045-1054(2002) [PubMed] [Europe PMC] [Abstract]
"Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange."
EMBO J. 25:3179-3190(2006) [PubMed] [Europe PMC] [Abstract]
"Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase."
Mol. Cell 35:818-829(2009) [PubMed] [Europe PMC] [Abstract]
"Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling."
J. Biol. Chem. 289:18258-18269(2014) [PubMed] [Europe PMC] [Abstract]
"Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome."
Science 286:2528-2531(1999) [PubMed] [Europe PMC] [Abstract]
"Mutation analysis of the CHK2 gene in families with hereditary breast cancer."
Br. J. Cancer 85:209-212(2001) [PubMed] [Europe PMC] [Abstract]
"Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome."
Cancer Res. 61:8062-8067(2001) [PubMed] [Europe PMC] [Abstract]
"Mutation analysis of the CHK2 gene in breast carcinoma and other cancers."
Breast Cancer Res. 4:R4-R4(2002) [PubMed] [Europe PMC] [Abstract]
"CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours."
Br. J. Cancer 87:1445-1448(2002) [PubMed] [Europe PMC] [Abstract]
"Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors."
Genes Chromosomes Cancer 33:17-21(2002) [PubMed] [Europe PMC] [Abstract]
"Mutations in CHEK2 associated with prostate cancer risk."
Am. J. Hum. Genet. 72:270-280(2003) [PubMed] [Europe PMC] [Abstract]
"Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility."
Am. J. Hum. Genet. 72:1023-1028(2003) [PubMed] [Europe PMC] [Abstract]
"CHEK2 variants associate with hereditary prostate cancer."
Br. J. Cancer 89:1966-1970(2003) [PubMed] [Europe PMC] [Abstract]
"CHEK2 is a multiorgan cancer susceptibility gene."
Am. J. Hum. Genet. 75:1131-1135(2004) [PubMed] [Europe PMC] [Abstract]
"Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women."
Breast Cancer Res. 6:R629-R635(2004) [PubMed] [Europe PMC] [Abstract]
"A novel founder CHEK2 mutation is associated with increased prostate cancer risk."
Cancer Res. 64:2677-2679(2004) [PubMed] [Europe PMC] [Abstract]
"Limited relevance of the CHEK2 gene in hereditary breast cancer."
Int. J. Cancer 110:320-325(2004) [PubMed] [Europe PMC] [Abstract]
"CHEK2 variant I157T may be associated with increased breast cancer risk."
Int. J. Cancer 111:543-547(2004) [PubMed] [Europe PMC] [Abstract]
"Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population."
Hum. Mol. Genet. 14:555-563(2005) [PubMed] [Europe PMC] [Abstract]
"Association of two mutations in the CHEK2 gene with breast cancer."
Int. J. Cancer 116:263-266(2005) [PubMed] [Europe PMC] [Abstract]
"Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype."
J. Pathol. 206:198-204(2005) [PubMed] [Europe PMC] [Abstract]
"A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk."
Oncogene 0:0-0(2015) [PubMed] [Europe PMC] [Abstract]