RAD23 Homolog B (RAD23B)

HHR23B; P58; HR23B; XP-C Repair Complementing Protein; XP-C Repair Complementing Complex 58 kDa; UV excision repair protein RAD23 homolog B

SPN	K302
HGNC	9813
MGI	105128
PubMed	23776089
RGD	1562958
UniProt	P54727
Wiki	RAD23B

RAD23B is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro.

This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

Reference

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"Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair."
Mol. Cell 2:223-232(1998) [PubMed] [Europe PMC] [Abstract]

"Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome."
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"Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites."
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"The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH."
DNA Repair 1:449-461(2002) [PubMed] [Europe PMC] [Abstract]

"DNA bending by the human damage recognition complex XPC-HR23B."
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"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
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Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct."
Biochemistry 49:669-678(2010) [PubMed] [Europe PMC] [Abstract]

"Stimulation of DNA glycosylase activities by XPC Protein Complex: Roles of protein-protein interactions."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a."
J. Biol. Chem. 278:36621-36627(2003) [PubMed] [Europe PMC] [Abstract]

"Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B."
J. Biol. Chem. 279:4760-4767(2004) [PubMed] [Europe PMC] [Abstract]

"Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B."
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