Myosin Light Chain 12A (MYL12A)

MLCB; MYL2B; MRLC3; MRCL3; HEL-S-24; RLC Myosin Regulatory Light Chain 3; Epididymis secretory protein Li 24; Myosin regulatory light chain 2, nonsarcomeric

SPN	J129
HGNC	16701
MGI	1914518
PubMed	21126233
UniProt	P19105

Myosins Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.

Some cytoskeletal proteins such as myosin light chain regulatory B 383 (MYL12B), destrin and regulator of microtubule dynamics protein 2 (FAM82A) were 384 strongly up-regulated by HFD (between a 1.5 and 2-fold increase).PLAA, related to 438 inflammation; myosin light chain regulatory B (MYL12B), which plays an important role in the 439 regulation of cell contractile activity and is implicated in cytokinesis, receptor capping, and cell 440 locomotion; several tropomyosins that bind actin filaments and have been recently found in the 441 wall of blood vessels in a portal area of liver .

Reference

"Human nonsarcomeric 20,000 Da myosin regulatory light chain cDNA."
Nucleic Acids Res. 18:5892-5892(1990) [PubMed] [Europe PMC] [Abstract]

"Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells."
Cell Struct. Funct. 26:677-683(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]