Gastrokine 3 (GKN3)

SPN	C872
MGI	1916138
PubMed	20138039
UniProt	Q9D0T7

A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans. Gkn3 encodes a secreted protein that is co-expressed with trefoil factor (Tff)2 in the distal stomach and discriminates a Griffinia simplicifolia lectin (GS)-II-positive mucus neck cell (MNC) subpopulation in the proximal stomach. In humans, widespread homozygosity for a premature stop codon polymorphism, W59X, has likely rendered GKN3 non-functional. Mouse Gkn3 expression is strongly up-regulated in (Tff2-deficient) gastric atrophy, a pre-cancerous state that is typically associated with Helicobacter pylori and marks a non-proliferative, GS-II positive lineage with features of spasmolytic polypeptide-expressing metaplasia (SPEM). Gkn3 overexpression inhibits proliferation in gastric epithelial cell lines, independently of incubation with recombinant human TFF2 or apoptosis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Hu01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Hu01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Hu01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Hu01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Hu01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Mu01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Mu01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Mu01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Mu01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Mu01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Ra01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Ra01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Ra01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Ra01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Ra01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Ca01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Ca01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Ca01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Ca01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Ca01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Po01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Po01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Po01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Po01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Po01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Bo01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Bo01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Bo01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Bo01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Bo01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Rb01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Rb01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Rb01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Rb01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Rb01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPC872Mo01	Recombinant Gastrokine 3 (GKN3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAC872Mo01	Monoclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IP.
Antibodies	PAC872Mo01	Polyclonal Antibody to Gastrokine 3 (GKN3)	WB; IHC; ICC; IF.
Assay Kits	CLC872Mo01	CLIA Kit for Gastrokine 3 (GKN3)	CLIA assay for Antigen Detection
Assay Kits	ELC872Mo01	ELISA Kit for Gastrokine 3 (GKN3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans."
Gastroenterology 138:1823-1835(2010) [PubMed] [Europe PMC] [Abstract]

"The transcriptional landscape of the mammalian genome."
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]