Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8)

CD30; KI-1; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30

SPN	W134
HGNC	11923
MGI	99908
PubMed	9826579
RGD	3879
UniProt	P28908
Wiki	TNFRSF8

TNFRSF8 is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus is a useful marker in distinguishing between these germ cell tumors.

Reference

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