Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1)
CD161; KLR-B1; CLEC5B; NKR; NKR-P1; NKR-P1A; NKRP1A; HNKR-P1A; C-type lectin domain family 5 member B; Natural killer cell surface protein P1A
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function.
The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or D161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Hu01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Hu01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Hu01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Hu01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Hu01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Mu01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Mu01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Mu01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Mu01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Mu01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Ra01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Ra01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Ra01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Ra01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Ra01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Ca01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Ca01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Ca01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Ca01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Ca01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Po01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Po01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Po01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Po01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Po01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Bo01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Bo01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Bo01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Bo01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Bo01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Rb01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Rb01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Rb01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Rb01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Rb01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV826Mo01 | Recombinant Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV826Mo01 | Monoclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IP. |
| PAV826Mo01 | Polyclonal Antibody to Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV826Mo01 | CLIA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | CLIA assay for Antigen Detection |
| ELV826Mo01 | ELISA Kit for Killer Cell Lectin Like Receptor Subfamily B, Member 1 (KLRB1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes."
J. Immunol. 153:2417-2428(1994) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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Eur. J. Immunol. 28:1611-1616(1998) [PubMed] [Europe PMC] [Abstract]
"CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver."
Clin. Exp. Immunol. 129:92-98(2002) [PubMed] [Europe PMC] [Abstract]
"Lectin-like transcript 1 is a ligand for the CD161 receptor."
J. Immunol. 175:7791-7795(2005) [PubMed] [Europe PMC] [Abstract]
"Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor."
J. Immunol. 175:7796-7799(2005) [PubMed] [Europe PMC] [Abstract]
"CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase."
J. Immunol. 176:2397-2406(2006) [PubMed] [Europe PMC] [Abstract]
"Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)."
Xenotransplantation 13:440-446(2006) [PubMed] [Europe PMC] [Abstract]
"Characterization of alternatively spliced transcript variants of CLEC2D gene."
J. Biol. Chem. 285:36207-36215(2010) [PubMed] [Europe PMC] [Abstract]