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Serum/Glucocorticoid Regulated Kinase 2 (SGK2)

Serine/threonine-protein kinase Sgk2

Serum/glucocorticoid regulated kinase 2, is a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids.

This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described. SGK2-alpha encodes a protein of 367 amino acids with a calculated molecular mass of about 41 kD. SGK2-beta encodes a protein of 427 amino acids with a calculated molecular mass of about 48 kD. SGK2 shares about 80% sequence identity with SGK1 and SGK3 (SGKL) within the central catalytic domain. Both the N and C termini share much less similarity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Hu01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Hu01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Hu01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Hu01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Hu01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Mu01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Mu01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Mu01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Mu01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Mu01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Ra01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Ra01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Ra01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Ra01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Ra01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Ca01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Ca01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Ca01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Ca01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Ca01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Po01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Po01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Po01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Po01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Po01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Bo01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Bo01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Bo01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Bo01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Bo01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Rb01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Rb01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Rb01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Rb01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Rb01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV117Mo01 Recombinant Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV117Mo01 Monoclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IP.
PAV117Mo01 Polyclonal Antibody to Serum/Glucocorticoid Regulated Kinase 2 (SGK2) WB; IHC; ICC; IF.
Assay Kits CLV117Mo01 CLIA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) CLIA assay for Antigen Detection
ELV117Mo01 ELISA Kit for Serum/Glucocorticoid Regulated Kinase 2 (SGK2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Pflugers Arch. 445:60-66(2002) [PubMed] [Europe PMC] [Abstract]

"Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms."
Pflugers Arch. 445:601-606(2003) [PubMed] [Europe PMC] [Abstract]

"The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC."
Pflugers Arch. 445:693-696(2003) [PubMed] [Europe PMC] [Abstract]

"Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1."
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"The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19."
Cell. Physiol. Biochem. 25:723-732(2010) [PubMed] [Europe PMC] [Abstract]

"Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids."
Mol. Biol. Cell 22:3812-3825(2011) [PubMed] [Europe PMC] [Abstract]

"Sgk kinases and their role in epithelial transport."
Annu. Rev. Physiol. 68:461-490(2006) [PubMed] [Europe PMC] [Abstract]

"Second AKT: the rise of SGK in cancer signalling."
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"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]