Folate Receptor 2, Fetal (FOLR2)

FBP/PL-1; FR-P3; FR-beta; beta-hFR; Folate receptor, fetal/placental; Placental folate-binding protein

SPN	U364
HGNC	3793
MGI	95569
PubMed	20683905
RGD	1308515
UniProt	P14207
Wiki	FOLR2

Folate receptor beta is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells.

This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.

Reference

"Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene."
J. Mol. Biol. 229:1175-1183(1993) [PubMed] [Europe PMC] [Abstract]

"Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA."
Biochemistry 28:8249-8254(1989) [PubMed] [Europe PMC] [Abstract]

"Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein."
J. Biol. Chem. 269:4725-4735(1994) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Folate coenzyme and antifolate transport proteins in normal and neoplastic cells."
Adv. Enzyme Regul. 29:13-26(1989) [PubMed] [Europe PMC] [Abstract]

"Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells."
J. Biol. Chem. 260:14911-14917(1985) [PubMed] [Europe PMC] [Abstract]

"Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal."
Biochemistry 34:14594-14600(1995) [PubMed] [Europe PMC] [Abstract]

"Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion."
Biochemistry 36:14583-14592(1997) [PubMed] [Europe PMC] [Abstract]

"All-trans retinoic acid is capable of inducing folate receptor beta expression in KG-1 cells."
Tumor Biol. 31:589-595(2010) [PubMed] [Europe PMC] [Abstract]

"Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition."
Proc. Natl. Acad. Sci. U.S.A. 110:15180-15188(2013) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]