Geranylgeranyl Diphosphate Synthase 1 (GGPS1)

GGPPS1; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase

SPN	U350
HGNC	4249
MGI	1341724
PubMed	10101267
RGD	1359680
UniProt	O95749
Wiki	GGPS1

Geranylgeranyl pyrophosphate synthetase is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The deduced protein shows 16% identity with farnesyl diphosphate synthase and contains 3 N-glycosylation sites as well as the 5 domains common to trans-prenyltransferases. expression in heart, skeletal muscle, and testis and the shorter transcript as the major species in these tissues.

Reference

"Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression."
J. Lipid Res. 39:1731-1739(1998) [PubMed] [Europe PMC] [Abstract]

"Human geranylgeranyl diphosphate synthase. cDNA cloning and expression."
J. Biol. Chem. 274:5888-5894(1999) [PubMed] [Europe PMC] [Abstract]

"Study on isolation of a geranylgeranyl pyrophosphate (GGPP) synthase cDNA and its expression -- development of a new assay system of gene functions."
Proc. Jpn. Conf. Biochem. Lipids 41:293-296(1999)

"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human."
Biochim. Biophys. Acta 1437:333-340(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding."
J. Biol. Chem. 281:22004-22012(2006) [PubMed] [Europe PMC] [Abstract]