Otoraplin (OTOR)

FDP; MIAL; MIAL1; Fibrocyte-derived protein; Melanoma inhibitory activity-like protein

SPN	U154
HGNC	8517
MGI	1888678
PubMed	10873378
RGD	1305253
UniProt	Q9NRC9
Wiki	OTOR

Otoraplin is a protein secreted via the Golgi apparatus and may function in cartilage development and maintenance. A frequent polymorphism in the translation start codon of this gene can abolish translation and may be associated with forms of deafness. This gene is a member of the melanoma-inhibiting activity gene family. In addition, alternate polyA sites exist for this gene.Human OTOR encodes a 128-amino acid protein with a predicted secretion signal peptide. The protein shares high sequence identity with the mouse (90%), chicken (80%), and bullfrog (60%) orthologs and with the related human CDRAP/MIA protein (43%). OTOR is translated as an approximately 15-kD polypeptide that is assembled into a covalently linked homodimer, modified by sulfation, and secreted from the cells via the Golgi apparatus.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Hu01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Hu01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Hu01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Hu01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Hu01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Mu01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Mu01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Mu01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Mu01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Mu01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Ra01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Ra01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Ra01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Ra01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Ra01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Ca01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Ca01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Ca01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Ca01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Ca01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Po01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Po01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Po01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Po01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Po01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Bo01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Bo01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Bo01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Bo01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Bo01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Rb01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Rb01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Rb01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Rb01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Rb01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU154Mo01	Recombinant Otoraplin (OTOR)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU154Mo01	Monoclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IP.
Antibodies	PAU154Mo01	Polyclonal Antibody to Otoraplin (OTOR)	WB; IHC; ICC; IF.
Assay Kits	CLU154Mo01	CLIA Kit for Otoraplin (OTOR)	CLIA assay for Antigen Detection
Assay Kits	ELU154Mo01	ELISA Kit for Otoraplin (OTOR)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A novel conserved cochlear gene, OTOR: identification, expression analysis, and chromosomal mapping."
Genomics 66:242-248(2000) [PubMed] [Europe PMC] [Abstract]

"Fdp, a new fibrocyte-derived protein related to MIA/CD-RAP, has an in vitro effect on the early differentiation of the inner ear mesenchyme."
J. Biol. Chem. 275:40036-40041(2000) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of an inner ear-expressed human melanoma inhibitory activity (MIA)-like gene (MIAL) with a frequent polymorphism that abolishes translation."
Genomics 71:40-52(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]