Torsin 1B (TOR1B)
DQ1; Torsin ATPase-1B; Torsin family 1 member B
By exon trapping on chromosome 9q34, screening fetal brain, adult frontal cortex, and adult liver cDNA libraries, and 5-prime and 3-prime RACE, Ozelius et al. (1997) cloned TOR1B, which they designated DQ1. The deduced 289-amino acid protein has a calculated molecular mass of more than 32 kD. TOR1B shares 69% amino acid identity with TOR1A, and both proteins contain an ATP-binding domain, 2 protein kinase C phosphorylation sites, a casein kinase II phosphorylation site, several N-myristoylation sites, and 6 conserved cysteines. Northern blot analysis detected expression of a 2.8-kb TOR1B transcript in adult brain, but not in fetal brain.TOR1B lies centromeric to TOR1A, and the 2 genes face in opposite orientations with their 3-prime ends about 2 kb apart.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Hu01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Hu01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Hu01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Hu01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Hu01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Mu01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Mu01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Mu01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Mu01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Mu01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Ra01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Ra01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Ra01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Ra01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Ra01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Ca01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Ca01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Ca01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Ca01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Ca01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Po01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Po01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Po01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Po01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Po01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Bo01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Bo01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Bo01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Bo01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Bo01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Rb01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Rb01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Rb01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Rb01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Rb01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ174Mo01 | Recombinant Torsin 1B (TOR1B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ174Mo01 | Monoclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IP. |
| PAQ174Mo01 | Polyclonal Antibody to Torsin 1B (TOR1B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ174Mo01 | CLIA Kit for Torsin 1B (TOR1B) | CLIA assay for Antigen Detection |
| ELQ174Mo01 | ELISA Kit for Torsin 1B (TOR1B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
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"TorsinB--perinuclear location and association with torsinA."
J. Neurochem. 89:1186-1194(2004) [PubMed] [Europe PMC] [Abstract]
"Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA."
Hum. Mol. Genet. 19:888-900(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Regulation of Torsin ATPases by LAP1 and LULL1."
Proc. Natl. Acad. Sci. U.S.A. 110:E1545-1554(2013) [PubMed] [Europe PMC] [Abstract]
"Arresting a Torsin ATPase reshapes the endoplasmic reticulum."
J. Biol. Chem. 289:552-564(2014) [PubMed] [Europe PMC] [Abstract]