Urocanase Domain Containing Protein 1 (UROC1)
Urocanase; Imidazolonepropionate hydrolase; Urocanate hydratase
Catabolism of histidine begins with the conversion of histidine to urocanic acid by histidase (HAL). UROC1, or urocanase (EC 4.2.1.49), catalyzes the second step in histidine catabolism, the metabolism of urocanic acid to formiminoglutamic acid.
Espinos et al. (2009) cloned human UROC1. The deduced protein contains a C-terminal catalytic domain with an evolutionarily conserved catalytic arginine (arg450). UROC1 had an apparent molecular mass of 74.8 kD by SDS-PAGE.Using a spectrophotometric assay, Espinos et al. (2009) demonstrated that purified recombinant UROC1 had robust urocanase activity.Espinos et al. (2009) determined that the UROC1 gene contains 20 exons.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Hu01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Hu01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Hu01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Hu01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Hu01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Mu01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Mu01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Mu01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Mu01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Mu01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Ra01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Ra01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Ra01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Ra01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Ra01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Ca01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Ca01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Ca01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Ca01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Ca01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Po01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Po01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Po01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Po01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Po01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Bo01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Bo01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Bo01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Bo01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Bo01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Rb01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Rb01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Rb01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Rb01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Rb01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO897Mo01 | Recombinant Urocanase Domain Containing Protein 1 (UROC1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO897Mo01 | Monoclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IP. |
| PAO897Mo01 | Polyclonal Antibody to Urocanase Domain Containing Protein 1 (UROC1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO897Mo01 | CLIA Kit for Urocanase Domain Containing Protein 1 (UROC1) | CLIA assay for Antigen Detection |
| ELO897Mo01 | ELISA Kit for Urocanase Domain Containing Protein 1 (UROC1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Mutations in the urocanase gene UROC1 are associated with urocanic aciduria."
J. Med. Genet. 46:407-411(2009) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]