A Disintegrin And Metalloproteinase With Thrombospondin 10 (ADAMTS10)

WMS; ADAM-TS10

SPN	N522
HGNC	13201
MGI	2449112
PubMed	21402694
UniProt	Q9H324
Wiki	ADAMTS10

ADAMTS10 belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.

The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.

Reference

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation."
J. Biol. Chem. 279:51208-51217(2004) [PubMed] [Europe PMC] [Abstract]

"ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome."
Am. J. Hum. Genet. 75:801-806(2004) [PubMed] [Europe PMC] [Abstract]

"ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts."
J. Biol. Chem. 286:17156-17167(2011) [PubMed] [Europe PMC] [Abstract]

"Functional analysis of an ADAMTS10 signal peptide mutation in Weill-Marchesani syndrome demonstrates a long-range effect on secretion of the full-length enzyme."
Hum. Mutat. 29:1425-1434(2008) [PubMed] [Europe PMC] [Abstract]