WD Repeat Containing Domain Protein 35 (WDR35)

IFT121; Intraflagellar transport protein 121 homolog

SPN	I951
HGNC	29250
MGI	1921932
PubMed	23227925
UniProt	Q9P2L0

WDR35 is WD40 domain-containing protein. Studies in mouse and several lower organisms have implicated WDR35 in intraflagellar transport. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The deduced 1,170-amino acid protein contains 4 N-terminal WD40 domains and shares 92.7% identity with human WDR35. Quantitative RT-PCR detected Wdr35 expression in all rat tissues examined, with highest expression in testis, followed by brain, and lowest expression in spleen.

Reference

"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"SnapShot: Intraflagellar transport."
Cell 137:784-784(2009) [PubMed] [Europe PMC] [Abstract]

"Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis."
Biochem. Biophys. Res. Commun. 394:153-157(2010) [PubMed] [Europe PMC] [Abstract]

"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia."
Genes Dev. 24:2180-2193(2010) [PubMed] [Europe PMC] [Abstract]

"Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis."
Am. J. Hum. Genet. 88:508-515(2011) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome."
Am. J. Hum. Genet. 87:418-423(2010) [PubMed] [Europe PMC] [Abstract]