Angiopoietin 2 (ANGPT2)
ANG2; AGPT2
Angiopoietin-2 (Ang-2) is a secreted glycoprotein that plays a complex role in vascular development. Ang-2 contains an N-terminal coiled-coildomain, 58 - 254 amino acids (aa) and a C-terminal fibrinogen-like domain, 281 - 467 aa, that is also found in other proteins including fibrinogen, tenascin, and ficolin. Located at the N-terminus are stretches of hydrophobic residues typical of secretory signal sequences. While Ang-2 is widely expressed in the mouse embryo, it is restricted postnatally to pro-angiogenic regions including the placenta, ovaries, and uterus. Ang-2 has been implicated in cancer development due to its role in angiogenesis.Ang-2-mediated destabilization of mature vessel structures accompanied by the presence of VEGF, may contribute to the angiogenesis associated with tumor tissues.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Hu01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Hu01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Hu01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Hu01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Hu01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Mu01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Mu01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Mu01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Mu01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Mu01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Ra01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Ra01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Ra01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Ra01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Ra01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Ca01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Ca01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Ca01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Ca01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Ca01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Po01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Po01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Po01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Po01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Po01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Bo01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Bo01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Bo01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Bo01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Bo01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Rb01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Rb01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Rb01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Rb01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Rb01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW696Mo01 | Recombinant Angiopoietin 2 (ANGPT2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW696Mo01 | Monoclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IP. |
| PAW696Mo01 | Polyclonal Antibody to Angiopoietin 2 (ANGPT2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW696Mo01 | CLIA Kit for Angiopoietin 2 (ANGPT2) | CLIA assay for Antigen Detection |
| ELW696Mo01 | ELISA Kit for Angiopoietin 2 (ANGPT2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."
Science 277:55-60(1997) [PubMed] [Europe PMC] [Abstract]
"Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma."
J. Clin. Invest. 103:341-345(1999) [PubMed] [Europe PMC] [Abstract]
"Characterization and expression of a novel alternatively spliced human angiopoietin-2."
J. Biol. Chem. 275:18550-18556(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."
J. Biol. Chem. 278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]
"Biological characterization of angiopoietin-3 and angiopoietin-4."
FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
"Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."
Angiogenesis 12:25-33(2009) [PubMed] [Europe PMC] [Abstract]
"Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."
Mol. Cell. Biol. 29:2011-2022(2009) [PubMed] [Europe PMC] [Abstract]
"Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
Nat. Rev. Mol. Cell Biol. 10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
"Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition."
Structure 13:825-832(2005) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex."
Nat. Struct. Mol. Biol. 13:524-532(2006) [PubMed] [Europe PMC] [Abstract]