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Brain Derived Neurotrophic Factor (BDNF)

Neurotrophin; Abrineurin

BDNF is a 13 kDa, 119 amino acid (aa) residue non-glycosylated polypeptide whose primary structure is conserved among all mammalian species examined. Initially synthesized as a 247 aa residue prepropeptide, the BDNF molecule is divided into an 18 aa residue signal sequence, a 110 aa residue prosequence, and a 119 aa residue mature segment.

Similar to other neurotrophic factors, there is a possibility that the N-terminus is alternatively spliced, giving rise to a longer pre-prosegment (but identical mature segment) with different functional properties. As a mature molecule, BDNF is 52% identical to NGF at the amino acid level, exists as a noncovalently-linked homodimer in solution, and contains six cysteine residues that are believed to form three intrachain disulfide linkages.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Hu01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Hu01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Hu01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Hu01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Hu01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Mu01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Mu01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Mu01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Mu01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Mu01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Ra01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Ra01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Ra01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Ra01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Ra01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Ca01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Ca01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Ca01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Ca01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Ca01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Po01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Po01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Po01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Po01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Po01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Bo01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Bo01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Bo01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Bo01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Bo01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Rb01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Rb01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Rb01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Rb01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Rb01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW694Mo01 Recombinant Brain Derived Neurotrophic Factor (BDNF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW694Mo01 Monoclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IP.
PAW694Mo01 Polyclonal Antibody to Brain Derived Neurotrophic Factor (BDNF) WB; IHC; ICC; IF.
Assay Kits CLW694Mo01 CLIA Kit for Brain Derived Neurotrophic Factor (BDNF) CLIA assay for Antigen Detection
ELW694Mo01 ELISA Kit for Brain Derived Neurotrophic Factor (BDNF) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of a human gene that is a member of the nerve growth factor family."
Proc. Natl. Acad. Sci. U.S.A. 87:8060-8064(1990) [PubMed] [Europe PMC] [Abstract]

"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]

"Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene."
Biochem. Biophys. Res. Commun. 182:325-332(1992) [PubMed] [Europe PMC] [Abstract]

"Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease."
Am. J. Med. Genet. B Neuropsychiatr. Genet. 134:93-103(2005) [PubMed] [Europe PMC] [Abstract]

"Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters."
Genomics 90:397-406(2007) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]

"Purification and identification of brain-derived neurotrophic factor from human serum."
Protein Expr. Purif. 6:465-471(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular phylogenetics and the origins of placental mammals."
Nature 409:614-618(2001) [PubMed] [Europe PMC] [Abstract]

"Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor."
J. Biol. Chem. 276:12660-12666(2001) [PubMed] [Europe PMC] [Abstract]

"Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations."
Hum. Mol. Genet. 13:1205-1212(2004) [PubMed] [Europe PMC] [Abstract]

"Brain-derived neurotrophic factor and obesity in the WAGR syndrome."
N. Engl. J. Med. 359:918-927(2008) [PubMed] [Europe PMC] [Abstract]

Erratum
N. Engl. J. Med. 359:1414-1414(2008)

"Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer."
Biochemistry 34:4139-4146(1995) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation."
Am. J. Med. Genet. 107:306-310(2002) [PubMed] [Europe PMC] [Abstract]

"Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder."
Am. J. Hum. Genet. 73:370-376(2003) [PubMed] [Europe PMC] [Abstract]

"The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function."
Cell 112:257-269(2003) [PubMed] [Europe PMC] [Abstract]

"Molecular analysis of congenital central hypoventilation syndrome."
Hum. Genet. 114:22-26(2003) [PubMed] [Europe PMC] [Abstract]

"Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type."
Mol. Psychiatry 8:745-751(2003) [PubMed] [Europe PMC] [Abstract]