Bone Morphogenetic Protein 4 (BMP4)
BMP2B; BMP2-B; BMP2B1; ZYME; DVR4; Bone morphogenetic protein 2B
BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5 untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Hu01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Hu01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Hu01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Hu01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Hu01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Mu01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Mu01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Mu01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Mu01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Mu01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Ra01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Ra01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Ra01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Ra01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Ra01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Ca01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Ca01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Ca01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Ca01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Ca01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Po01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Po01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Po01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Po01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Po01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Bo01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Bo01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Bo01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Bo01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Bo01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Rb01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Rb01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Rb01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Rb01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Rb01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW692Mo01 | Recombinant Bone Morphogenetic Protein 4 (BMP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW692Mo01 | Monoclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IP. |
| PAW692Mo01 | Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW692Mo01 | CLIA Kit for Bone Morphogenetic Protein 4 (BMP4) | CLIA assay for Antigen Detection |
| ELW692Mo01 | ELISA Kit for Bone Morphogenetic Protein 4 (BMP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Novel regulators of bone formation: molecular clones and activities."
Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
"The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation."
Calcif. Tissue Int. 63:221-229(1998) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library."
DNA Seq. 5:273-275(1995) [PubMed] [Europe PMC] [Abstract]
"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."
Biochem. Biophys. Res. Commun. 316:490-500(2004) [PubMed] [Europe PMC] [Abstract]
"Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)."
Eur. J. Hum. Genet. 10:753-756(2002) [PubMed] [Europe PMC] [Abstract]
"Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways."
Am. J. Hum. Genet. 82d:304-319(2008) [PubMed] [Europe PMC] [Abstract]
"SIX2 and BMP4 mutations associate with anomalous kidney development."
J. Am. Soc. Nephrol. 19:891-903(2008) [PubMed] [Europe PMC] [Abstract]
"Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip."
Am. J. Hum. Genet. 84:406-411(2009) [PubMed] [Europe PMC] [Abstract]