Ciliary Neurotrophic Factor (CNTF)
HCNTF
Ciliary neurotrophic factor is a polypeptide hormone and nerve growth factor whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations including astrocytes. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks.
A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Hu01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Hu01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Hu01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Hu01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Hu01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Mu01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Mu01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Mu01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Mu01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Mu01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Ra01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Ra01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Ra01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Ra01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Ra01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Ca01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Ca01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Ca01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Ca01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Ca01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Po01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Po01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Po01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Po01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Po01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Bo01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Bo01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Bo01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Bo01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Bo01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Rb01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Rb01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Rb01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Rb01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Rb01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW685Mo01 | Recombinant Ciliary Neurotrophic Factor (CNTF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW685Mo01 | Monoclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IP. |
| PAW685Mo01 | Polyclonal Antibody to Ciliary Neurotrophic Factor (CNTF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW685Mo01 | CLIA Kit for Ciliary Neurotrophic Factor (CNTF) | CLIA assay for Antigen Detection |
| ELW685Mo01 | ELISA Kit for Ciliary Neurotrophic Factor (CNTF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Recombinant human and rat ciliary neurotrophic factors."
J. Neurochem. 57:1003-1012(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of human ciliary neurotrophic factor."
Eur. J. Biochem. 201:289-294(1991) [PubMed] [Europe PMC] [Abstract]
"Sequence and structural organization of the human gene encoding ciliary neurotrophic factor."
Gene 102:271-276(1991) [PubMed] [Europe PMC] [Abstract]
"Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli."
Biochim. Biophys. Acta 1090:70-80(1991) [PubMed] [Europe PMC] [Abstract]
"A null mutation in the human CNTF gene is not causally related to neurological diseases."
Nat. Genet. 7:79-84(1994) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing."
EMBO J. 14:2689-2699(1995) [PubMed] [Europe PMC] [Abstract]
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
Nat. Genet. 23:373-373(1999)