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Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF)

PK1; EGVEGF; PRK1, PROK1; Prokineticin 1; Black Mamba Toxin-Related Protein; Mambakine

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation, migration, and fenestration in capillary endothelial cells derived from endocrine glands. Its expression is induced by hypoxia and is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta). Its expression is often complementary to the expression of VEGF, suggesting that these molecules function in a coordinated manner.

EG-VEGF is mitogenic and chemoattractive and able to induce fenestration. EG-VEGF expression is induced by hypoxia, and there is an HIF1 binding site present on EG-VEGF. EG-VEGF is able to induce angiogenesis and ovarian cyst formation. Northern blot analysis demonstrated expression in testis, ovary, adrenal gland, and placenta.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Hu01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Hu01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Hu01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Hu01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Hu01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Mu01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Mu01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Mu01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Mu01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Mu01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Ra01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Ra01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Ra01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Ra01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Ra01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Ca01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Ca01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Ca01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Ca01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Ca01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Po01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Po01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Po01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Po01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Po01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Bo01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Bo01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Bo01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Bo01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Bo01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Rb01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Rb01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Rb01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Rb01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Rb01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW682Mo01 Recombinant Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW682Mo01 Monoclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IP.
PAW682Mo01 Polyclonal Antibody to Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) WB; IHC; ICC; IF.
Assay Kits CLW682Mo01 CLIA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) CLIA assay for Antigen Detection
ELW682Mo01 ELISA Kit for Endocrine Gland Derived Vascular Endothelial Growth Factor (EG-VEGF) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Mol. Pharmacol. 59:692-698(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of an angiogenic mitogen selective for endocrine gland endothelium."
Nature 412:877-884(2001) [PubMed] [Europe PMC] [Abstract]

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"Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis."
J. Clin. Endocrinol. Metab. 89:4078-4088(2004) [PubMed] [Europe PMC] [Abstract]

"Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression."
Clin. Cancer Res. 13:868-875(2007) [PubMed] [Europe PMC] [Abstract]

"Prokineticin 1 signaling and gene regulation in early human pregnancy."
Endocrinology 149:2877-2887(2008) [PubMed] [Europe PMC] [Abstract]