Eosinophil Chemotactic Factor (ECF)
CCL11; SCYA11; Eotaxin 1; Eosinophil Chemotactic Protein 1; Chemokine C-C-Motif Ligand 11; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 11
An eosinophil chemotactic factor (ECF) can be released from human polymorphonuclear neutrophils (PMN), rat mononuclear and rat mast cells by the calcium ionophore, during phagocytosis, by arachidonic acid and phospholipase A2. It has been suggested that stimuli such as the ionophore and the phagocytic event lead to phospholipid turnover with the generation of arachidonic acid which is subsequently transformed by a lipoxygenase-like enzyme into ECF.
Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Hu01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Hu01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Hu01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Hu01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Hu01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Mu01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Mu01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Mu01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Mu01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Mu01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Ra01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Ra01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Ra01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Ra01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Ra01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Ca01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Ca01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Ca01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Ca01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Ca01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Po01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Po01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Po01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Po01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Po01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Bo01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Bo01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Bo01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Bo01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Bo01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Rb01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Rb01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Rb01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Rb01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Rb01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW681Mo01 | Recombinant Eosinophil Chemotactic Factor (ECF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW681Mo01 | Monoclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IP. |
| PAW681Mo01 | Polyclonal Antibody to Eosinophil Chemotactic Factor (ECF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW681Mo01 | CLIA Kit for Eosinophil Chemotactic Factor (ECF) | CLIA assay for Antigen Detection |
| ELW681Mo01 | ELISA Kit for Eosinophil Chemotactic Factor (ECF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia."
Nat. Med. 2:449-456(1996) [PubMed] [Europe PMC] [Abstract]
"Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils."
J. Clin. Invest. 97:604-612(1996) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3."
J. Biol. Chem. 271:7725-7730(1996) [PubMed] [Europe PMC] [Abstract]
"Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants."
Biochem. Biophys. Res. Commun. 225:1045-1051(1996) [PubMed] [Europe PMC] [Abstract]
"Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine."
Genomics 41:471-476(1997) [PubMed] [Europe PMC] [Abstract]
"Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene."
Biochem. Biophys. Res. Commun. 237:537-542(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts."
Eur. J. Biochem. 253:114-122(1998) [PubMed] [Europe PMC] [Abstract]
"Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation."
J. Biol. Chem. 273:22471-22479(1998) [PubMed] [Europe PMC] [Abstract]