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Selectin, Endothelium (SELE)

CD62E; CD62-E; E-Selectin; ELAM; ELAM1; ESEL; SEL-E; E-LAM; E-LAM1; E-SEL; LECAM2; Endothelial Leukocyte Adhesion Molecule 1; CD62 Antigen-Like Family Member E

CD62E is also known as endothelial leukocyte adhesion molecule 1 (ELAM1) or E selectin. It is a type I membrane protein that belongs to the selectin family of surface molecules (along with CD62L and CD62P). Selectins are C type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium.

CD62E (E selectin) is an endothelial cell specific selectin that is expressed on cytokine induced endothelial cells only after activation with proinflammatory cytokines. In vitro experiments have shown that IL1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of CD62E in an NFkB dependent signalling cascade. CD62E has been associated with blood vessel endothelium in diverse inflammatory situations.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Hu01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Hu01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Hu01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Hu01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Hu01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Mu01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Mu01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Mu01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Mu01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Mu01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Ra01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Ra01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Ra01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Ra01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Ra01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Ca01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Ca01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Ca01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Ca01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Ca01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Po01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Po01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Po01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Po01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Po01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Bo01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Bo01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Bo01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Bo01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Bo01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Rb01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Rb01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Rb01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Rb01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Rb01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW677Mo01 Recombinant Selectin, Endothelium (SELE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW677Mo01 Monoclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IP.
PAW677Mo01 Polyclonal Antibody to Selectin, Endothelium (SELE) WB; IHC; ICC; IF.
Assay Kits CLW677Mo01 CLIA Kit for Selectin, Endothelium (SELE) CLIA assay for Antigen Detection
ELW677Mo01 ELISA Kit for Selectin, Endothelium (SELE) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions."
Proc. Natl. Acad. Sci. U.S.A. 87:1673-1677(1990) [PubMed] [Europe PMC] [Abstract]

"Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins."
Science 243:1160-1165(1989) [PubMed] [Europe PMC] [Abstract]

"Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1."
J. Biol. Chem. 266:2466-2473(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex."
Science 250:1130-1132(1990) [PubMed] [Europe PMC] [Abstract]

"Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins."
J. Immunol. 181:1480-1490(2008) [PubMed] [Europe PMC] [Abstract]

"Modelling the carbohydrate recognition domain of human E-selectin."
FEBS Lett. 319:5-11(1993) [PubMed] [Europe PMC] [Abstract]

"Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains."
Nature 367:532-538(1994) [PubMed] [Europe PMC] [Abstract]

"Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."
Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]

Erratum
Cell 105:971-971(2001)

"E-selectin polymorphism and atherosclerosis: an association study."
Hum. Mol. Genet. 3:1935-1937(1994) [PubMed] [Europe PMC] [Abstract]

"DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis."
Hum. Genet. 97:15-20(1996) [PubMed] [Europe PMC] [Abstract]

"A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease."
J. Biomed. Sci. 6:18-21(1999) [PubMed] [Europe PMC] [Abstract]

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

"Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort."
Hum. Genet. 107:58-61(2000) [PubMed] [Europe PMC] [Abstract]

"E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions."
Arterioscler. Thromb. Vasc. Biol. 23:783-788(2003) [PubMed] [Europe PMC] [Abstract]

"Implications of the E-selectin S128R mutation for drug discovery."
Glycobiology 24:592-601(2014) [PubMed] [Europe PMC] [Abstract]