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Factor Related Apoptosis (FAS)

CD95; ALPS1A; ALPS1-A; APO1; APT1; FAS1; FASTM; TNFRSF6; Fas Receptor; TNF Receptor Superfamily Member 6; Tumor Necrosis Factor Receptor Superfamily Member 6

Fas  is a glycoprotein with a mass estimated at 43 to 48 kDa . Fas is a member of the Tumor Necrosis Factor Receptor Superfamily (TNFRSF), and it shares a cytoplasmic motif with TNF RI, referred to as the death domain, that binds cytoplasm signaling molecules to trigger the cytoplasmic apoptotic signal . Fas is expressed to a large extent on activated T and B lymphocytes, and on malignant lymphoid cells. To a lesser extent, Fas is expressed on cells from liver, heart, kidney, ovaries, and on many other malignant cells.
Yan et al. (2005) noted that the TNFRSF6 gene contains 9 exons. They identified an antisense transcript SAF within the 12.1-kb intron 1 that is transcribed in the opposite direction as the TNFRSF6 gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Hu01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Hu01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Hu01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Hu01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Hu01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Mu01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Mu01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Mu01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Mu01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Mu01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Ra01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Ra01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Ra01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Ra01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Ra01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Ca01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Ca01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Ca01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Ca01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Ca01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Po01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Po01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Po01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Po01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Po01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Bo01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Bo01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Bo01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Bo01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Bo01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Rb01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Rb01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Rb01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Rb01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Rb01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW676Mo01 Recombinant Factor Related Apoptosis (FAS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW676Mo01 Monoclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IP.
PAW676Mo01 Polyclonal Antibody to Factor Related Apoptosis (FAS) WB; IHC; ICC; IF.
Assay Kits CLW676Mo01 CLIA Kit for Factor Related Apoptosis (FAS) CLIA assay for Antigen Detection
ELW676Mo01 ELISA Kit for Factor Related Apoptosis (FAS) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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Cell 66:233-243(1991) [PubMed] [Europe PMC] [Abstract]

"Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen."
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"Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation."
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"Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing."
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"Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis."
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"An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro."
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"Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation."
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death."
Cell 81:513-523(1995) [PubMed] [Europe PMC] [Abstract]

"F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis."
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"LFG: an anti-apoptotic gene that provides protection from fas-mediated cell death."
Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
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"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
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"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
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"Whole-exome-sequencing-based discovery of human FADD deficiency."
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"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain."
Nature 384:638-641(1996) [PubMed] [Europe PMC] [Abstract]

"The Fas-FADD death domain complex structure unravels signalling by receptor clustering."
Nature 457:1019-1022(2009) [PubMed] [Europe PMC] [Abstract]

"Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome."
Cell 81:935-946(1995) [PubMed] [Europe PMC] [Abstract]

"Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity."
N. Engl. J. Med. 335:1643-1649(1996) [PubMed] [Europe PMC] [Abstract]

"Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis."
Blood 89:902-909(1997) [PubMed] [Europe PMC] [Abstract]

"Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis."
Blood 89:1341-1348(1997) [PubMed] [Europe PMC] [Abstract]

"Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis."
Gastroenterology 113:1384-1389(1997) [PubMed] [Europe PMC] [Abstract]

"Somatic Fas mutations in non-Hodgkin's lymphoma: association with extranodal disease and autoimmunity."
Blood 92:3018-3024(1998) [PubMed] [Europe PMC] [Abstract]

"The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis."
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"Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations."
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"The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations."
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"Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar."
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"The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis."
Blood 98:194-200(2001) [PubMed] [Europe PMC] [Abstract]

"The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations."
Nat. Struct. Mol. Biol. 17:1324-1329(2010) [PubMed] [Europe PMC] [Abstract]