Interferon Alpha (IFNa)
IFNA1; IFL; LeIF D; IFN; IFN-Alpha; IFNA13; IFN-A; IFNAP22; IFN-Alpha 1b; Interferon Alpha 1b; Interferon, Leukocytic; IFN, Leukocyte; Interferon alpha-D
Streuli et al. (1980) showed that at least 3 different IFN-alpha genes are expressed in man. Furthermore, study of genomic DNA revealed the presence of at least 8 IFN genes.
Nagata et al. (1980) found that the alpha-interferon genes are devoid of intervening sequences. Using radioactive probes from purified cDNA clones of interferons, Owerbach et al. (1981) located at least 8 leukocyte interferon genes and a fibroblast interferon gene on chromosome 9. Shows et al. (1982) found that the alpha- and beta-interferon genes are on 9p. The mapping to 9pter-q12 was accomplished by blot hybridization of cloned interferon cDNA to DNA from human-mouse cell hybrids with a translocation involving chromosome 9.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Hu01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Hu01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Hu01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Hu01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Hu01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Mu01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Mu01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Mu01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Mu01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Mu01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Ra01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Ra01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Ra01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Ra01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Ra01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Ca01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Ca01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Ca01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Ca01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Ca01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Po01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Po01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Po01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Po01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Po01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Bo01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Bo01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Bo01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Bo01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Bo01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Rb01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Rb01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Rb01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Rb01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Rb01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW673Mo01 | Recombinant Interferon Alpha (IFNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW673Mo01 | Monoclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IP. |
| PAW673Mo01 | Polyclonal Antibody to Interferon Alpha (IFNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW673Mo01 | CLIA Kit for Interferon Alpha (IFNa) | CLIA assay for Antigen Detection |
| ELW673Mo01 | ELISA Kit for Interferon Alpha (IFNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The nucleotide sequence of a cloned human leukocyte interferon cDNA."
Gene 10:1-10(1980) [PubMed] [Europe PMC] [Abstract]
"Human leukocyte and fibroblast interferons are structurally related."
Nature 285:547-549(1980) [PubMed] [Europe PMC] [Abstract]
"The structure of eight distinct cloned human leukocyte interferon cDNAs."
Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
"Two non-allelic human interferon alpha genes with identical coding regions."
EMBO J. 3:1809-1812(1984) [PubMed] [Europe PMC] [Abstract]
"Structural relationship of human interferon alpha genes and pseudogenes."
J. Mol. Biol. 185:227-260(1985) [PubMed] [Europe PMC] [Abstract]
"Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
"Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-alpha 1 mRNA."
Med. Mol. Morphol. 43:145-157(2010) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli."
Nucleic Acids Res. 11:5661-5669(1983) [PubMed] [Europe PMC] [Abstract]
"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
"IFN-alpha-1a gene is the major variant in the North American population."
J. Interferon Cytokine Res. 20:763-768(2000) [PubMed] [Europe PMC] [Abstract]
"Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus."
J. Mol. Med. 90:837-846(2012) [PubMed] [Europe PMC] [Abstract]