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Neutrophil Activating Protein 3 (NAP3)

CXCL1; GRO1; GROa; GRO-A; MGSA-A; NAP3; SCYB1; Chemokine C-X-C-Motif Ligand 1; Melanoma Growth Stimulating Activity Alpha; Fibroblast Secretory Protein

CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis.CXCL1 is expressed by macrophages, neutrophils and epithelial cells,and has neutrophil chemoattractant activity.CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.

This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines.An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Hu01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Hu01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Hu01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Hu01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Hu01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Mu01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Mu01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Mu01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Mu01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Mu01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Ra01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Ra01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Ra01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Ra01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Ra01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Ca01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Ca01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Ca01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Ca01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Ca01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Po01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Po01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Po01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Po01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Po01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Bo01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Bo01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Bo01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Bo01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Bo01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Rb01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Rb01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Rb01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Rb01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Rb01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW665Mo01 Recombinant Neutrophil Activating Protein 3 (NAP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW665Mo01 Monoclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IP.
PAW665Mo01 Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3) WB; IHC; ICC; IF.
Assay Kits CLW665Mo01 CLIA Kit for Neutrophil Activating Protein 3 (NAP3) CLIA assay for Antigen Detection
ELW665Mo01 ELISA Kit for Neutrophil Activating Protein 3 (NAP3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin."
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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity."
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"Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale."
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"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
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"Expression and secretion of gro/MGSA by stimulated human endothelial cells."
EMBO J. 8:1761-1766(1989) [PubMed] [Europe PMC] [Abstract]

"1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy."
FEBS Lett. 330:302-306(1993) [PubMed] [Europe PMC] [Abstract]

"The solution structure of melanoma growth stimulating activity."
J. Mol. Biol. 242:252-270(1994) [PubMed] [Europe PMC] [Abstract]

"Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy."
J. Biol. Chem. 269:32909-32915(1994) [PubMed] [Europe PMC] [Abstract]