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Glycoprotein 130 (gp130)

CDw130; CD130; IL6ST; GP130-RAPS; IR6RB; IL6R-Beta; IR6RB; IR6-RB; Interleukin 6 Signal Transducer; Oncostatin M Receptor; Interleukin-6 Receptor Subunit Beta

Glycoprotein 130 is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement.

As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Hu01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Hu01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Hu01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Hu01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Hu01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Mu01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Mu01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Mu01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Mu01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Mu01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Ra01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Ra01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Ra01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Ra01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Ra01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Ca01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Ca01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Ca01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Ca01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Ca01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Po01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Po01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Po01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Po01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Po01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Bo01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Bo01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Bo01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Bo01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Bo01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Rb01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Rb01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Rb01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Rb01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Rb01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW660Mo01 Recombinant Glycoprotein 130 (gp130) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW660Mo01 Monoclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IP.
PAW660Mo01 Polyclonal Antibody to Glycoprotein 130 (gp130) WB; IHC; ICC; IF.
Assay Kits CLW660Mo01 CLIA Kit for Glycoprotein 130 (gp130) CLIA assay for Antigen Detection
ELW660Mo01 ELISA Kit for Glycoprotein 130 (gp130) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

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Science 291:2150-2155(2001) [PubMed] [Europe PMC] [Abstract]

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Mol. Cell 12:577-589(2003) [PubMed] [Europe PMC] [Abstract]

"Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."
Science 300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]