Hepatocyte Growth Factor (HGF)
HGF; F-TCF; HGFB; HPTA; SF; Scatter Factor; Hepapoietin A; Fibroblast-Derived Tumor Cytotoxic Factor; Lung Fibroblast-Derived Mitogen
scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Hu01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Hu01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Hu01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Hu01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Hu01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Mu01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Mu01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Mu01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Mu01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Mu01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Ra01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Ra01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Ra01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Ra01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Ra01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Ca01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Ca01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Ca01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Ca01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Ca01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Po01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Po01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Po01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Po01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Po01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Bo01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Bo01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Bo01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Bo01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Bo01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Rb01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Rb01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Rb01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Rb01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Rb01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW659Mo01 | Recombinant Hepatocyte Growth Factor (HGF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW659Mo01 | Monoclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IP. |
| PAW659Mo01 | Polyclonal Antibody to Hepatocyte Growth Factor (HGF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW659Mo01 | CLIA Kit for Hepatocyte Growth Factor (HGF) | CLIA assay for Antigen Detection |
| ELW659Mo01 | ELISA Kit for Hepatocyte Growth Factor (HGF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor."
Biochem. Biophys. Res. Commun. 163:967-973(1989) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and expression of human hepatocyte growth factor."
Nature 342:440-443(1989) [PubMed] [Europe PMC] [Abstract]
"Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte."
Biochem. Biophys. Res. Commun. 172:321-327(1990) [PubMed] [Europe PMC] [Abstract]
"Organization of the human hepatocyte growth factor-encoding gene."
Gene 102:213-219(1991) [PubMed] [Europe PMC] [Abstract]
"An alternatively processed mRNA generated from human hepatocyte growth factor gene."
Eur. J. Biochem. 197:15-22(1991) [PubMed] [Europe PMC] [Abstract]
"A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor."
Proc. Natl. Acad. Sci. U.S.A. 88:415-419(1991) [PubMed] [Europe PMC] [Abstract]
"Evidence for the identity of human scatter factor and human hepatocyte growth factor."
Proc. Natl. Acad. Sci. U.S.A. 88:7001-7005(1991) [PubMed] [Europe PMC] [Abstract]
"Identification of a competitive HGF antagonist encoded by an alternative transcript."
Science 254:1382-1385(1991) [PubMed] [Europe PMC] [Abstract]
"A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis."
Proc. Natl. Acad. Sci. U.S.A. 89:11574-11578(1992) [PubMed] [Europe PMC] [Abstract]
"Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity."
J. Biol. Chem. 271:13110-13115(1996) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Structural organization and the transcription initiation site of the human hepatocyte growth factor gene."
Biochemistry 30:9170-9176(1991) [PubMed] [Europe PMC] [Abstract]
"Identification of the N-terminal residue of the heavy chain of both native and recombinant human hepatocyte growth factor."
Biochem. Biophys. Res. Commun. 175:660-667(1991) [PubMed] [Europe PMC] [Abstract]
"Hepatocyte growth factor is linked by O-glycosylated oligosaccharide on the alpha chain."
Biochem. Biophys. Res. Commun. 189:1329-1335(1992) [PubMed] [Europe PMC] [Abstract]
"Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding."
EMBO J. 11:2503-2510(1992) [PubMed] [Europe PMC] [Abstract]
"Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39."
Am. J. Hum. Genet. 85:25-39(2009) [PubMed] [Europe PMC] [Abstract]
"SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer."
PLoS ONE 7:E27922-E27922(2012) [PubMed] [Europe PMC] [Abstract]
"The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site."
Structure 6:109-116(1998) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0-A resolution."
Structure 6:1383-1393(1998) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor."
EMBO J. 23:2325-2335(2004) [PubMed] [Europe PMC] [Abstract]
"Structural basis for agonism and antagonism of hepatocyte growth factor."
Proc. Natl. Acad. Sci. U.S.A. 107:13264-13269(2010) [PubMed] [Europe PMC] [Abstract]