Interleukin 13 (IL13)
ALRH; BHR1; P600; IL-13; NC30
Interleukin 13 (IL-13) is produced primarily by activated T lymphocytes. It shows approximately 30% amino acid (aa) sequence identity with IL-4 and shares many biological properties with IL-4. IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. It can suppress the cytotoxic functions of monocytes/macrophages and the production of proinflammatory cytokines by monocytes/macrophages. The biological effects of IL-13 are mediated by specific high-affinity cell surface receptor complexes. The functional IL-13 receptor complex has been shown to consist of the low-affinity IL-13 receptor α chain and the IL-4 receptor α subunit (IL-4 Rα). This IL-13 receptor complex may also serve as an alternate high-affinity IL-4 receptor complex in IL-4 responsive cells that lack the γ chain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Hu01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Hu01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Hu01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Hu01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Hu01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Mu01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Mu01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Mu01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Mu01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Mu01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Ra01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Ra01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Ra01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Ra01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Ra01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Ca01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Ca01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Ca01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Ca01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Ca01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Po01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Po01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Po01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Po01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Po01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Bo01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Bo01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Bo01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Bo01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Bo01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Rb01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Rb01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Rb01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Rb01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Rb01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW647Mo01 | Recombinant Interleukin 13 (IL13) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW647Mo01 | Monoclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IP. |
| PAW647Mo01 | Polyclonal Antibody to Interleukin 13 (IL13) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW647Mo01 | CLIA Kit for Interleukin 13 (IL13) | CLIA assay for Antigen Detection |
| ELW647Mo01 | ELISA Kit for Interleukin 13 (IL13) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses."
Nature 362:248-250(1993) [PubMed] [Europe PMC] [Abstract]
"Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function."
Proc. Natl. Acad. Sci. U.S.A. 90:3735-3739(1993) [PubMed] [Europe PMC] [Abstract]
"Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization."
Gene 155:277-281(1995) [PubMed] [Europe PMC] [Abstract]
"Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31."
Blood 87:3316-3326(1996) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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Nucleic Acids Res. 20:5173-5179(1992) [PubMed] [Europe PMC] [Abstract]
"Solution structure of human IL-13 and implication for receptor binding."
J. Mol. Biol. 310:219-230(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2."
Structure 18:332-342(2010) [PubMed] [Europe PMC] [Abstract]
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Hum. Mol. Genet. 9:549-559(2000) [PubMed] [Europe PMC] [Abstract]
"Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population."
Am. J. Respir. Cell Mol. Biol. 25:377-384(2001) [PubMed] [Europe PMC] [Abstract]
"A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis."
Hum. Genet. 113:387-390(2003) [PubMed] [Europe PMC] [Abstract]