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Interleukin 1 Receptor Type II (IL1R2)

CD121b; CD121-B; IL1-R2; IL1RB; Interleukin-1 Receptor Beta; CD121 Antigen-like Family Member B

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family.

This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Hu01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Hu01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Hu01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Hu01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Hu01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Mu01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Mu01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Mu01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Mu01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Mu01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Ra01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Ra01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Ra01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Ra01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Ra01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Ca01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Ca01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Ca01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Ca01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Ca01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Po01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Po01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Po01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Po01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Po01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Bo01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Bo01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Bo01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Bo01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Bo01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Rb01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Rb01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Rb01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Rb01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Rb01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW642Mo01 Recombinant Interleukin 1 Receptor Type II (IL1R2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW642Mo01 Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IP.
PAW642Mo01 Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) WB; IHC; ICC; IF.
Assay Kits CLW642Mo01 CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) CLIA assay for Antigen Detection
ELW642Mo01 ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types."
EMBO J. 10:2821-2832(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA."
J. Biol. Chem. 271:20965-20972(1996) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses."
J. Immunol. 153:5802-5809(1994) [PubMed] [Europe PMC] [Abstract]

"Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist."
Proc. Natl. Acad. Sci. U.S.A. 92:1714-1718(1995) [PubMed] [Europe PMC] [Abstract]

"Role of metalloproteases in the release of the IL-1 type II decoy receptor."
J. Biol. Chem. 272:31764-31769(1997) [PubMed] [Europe PMC] [Abstract]

"The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness."
J. Immunol. 161:6871-6877(1998) [PubMed] [Europe PMC] [Abstract]

"The membrane form of the type II IL-1 receptor accounts for inhibitory function."
J. Immunol. 165:3350-3357(2000) [PubMed] [Europe PMC] [Abstract]

"The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."
Immunity 18:87-96(2003) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the assembly and activation of IL-1beta with its receptors."
Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]