Interleukin 1 Receptor Type II (IL1R2)
CD121b; CD121-B; IL1-R2; IL1RB; Interleukin-1 Receptor Beta; CD121 Antigen-like Family Member B
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family.
This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Hu01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Hu01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Hu01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Hu01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Hu01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Mu01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Mu01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Mu01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Mu01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Mu01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Ra01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Ra01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Ra01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Ra01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Ra01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Ca01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Ca01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Ca01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Ca01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Ca01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Po01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Po01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Po01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Po01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Po01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Bo01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Bo01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Bo01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Bo01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Bo01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Rb01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Rb01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Rb01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Rb01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Rb01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW642Mo01 | Recombinant Interleukin 1 Receptor Type II (IL1R2) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW642Mo01 | Monoclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IP. |
PAW642Mo01 | Polyclonal Antibody to Interleukin 1 Receptor Type II (IL1R2) | WB; IHC; ICC; IF. | |
Assay Kits | CLW642Mo01 | CLIA Kit for Interleukin 1 Receptor Type II (IL1R2) | CLIA assay for Antigen Detection |
ELW642Mo01 | ELISA Kit for Interleukin 1 Receptor Type II (IL1R2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types."
EMBO J. 10:2821-2832(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA."
J. Biol. Chem. 271:20965-20972(1996) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses."
J. Immunol. 153:5802-5809(1994) [PubMed] [Europe PMC] [Abstract]
"Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist."
Proc. Natl. Acad. Sci. U.S.A. 92:1714-1718(1995) [PubMed] [Europe PMC] [Abstract]
"Role of metalloproteases in the release of the IL-1 type II decoy receptor."
J. Biol. Chem. 272:31764-31769(1997) [PubMed] [Europe PMC] [Abstract]
"The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness."
J. Immunol. 161:6871-6877(1998) [PubMed] [Europe PMC] [Abstract]
"The membrane form of the type II IL-1 receptor accounts for inhibitory function."
J. Immunol. 165:3350-3357(2000) [PubMed] [Europe PMC] [Abstract]
"The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."
Immunity 18:87-96(2003) [PubMed] [Europe PMC] [Abstract]
"Structural insights into the assembly and activation of IL-1beta with its receptors."
Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]