Call Now

Interleukin 2 (IL2)

TCGF; Lymphokine; T-Cell Growth Factor; Aldesleukin

Interleukin 2 (IL-2) is a pleiotropic cytokine produced primarily by mitogen- or antigen-activated T lymphocytes. IL-2 plays a key role in promoting the clonal expansion of antigen-specific T cells. In addition, IL-2 has also been shown to mediate multiple immune responses on a variety of cell types.

IL-2 stimulates the proliferation of thymocytes; stimulates the proliferation and differentiation of activated B cells; promotes the growth, differentiation and cytocidal activity of monocytes; induces the growth of and cytokine production and cytolytic activity by natural killer cells; enhances the production of lymphocyte-activated killer (LAK) cells; and induces the proliferation and differentiation of oligodendrocytes .

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Hu01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Hu01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Hu01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Hu01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Hu01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Mu01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Mu01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Mu01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Mu01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Mu01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Ra01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Ra01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Ra01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Ra01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Ra01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Ca01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Ca01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Ca01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Ca01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Ca01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Po01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Po01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Po01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Po01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Po01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Bo01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Bo01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Bo01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Bo01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Bo01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Rb01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Rb01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Rb01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Rb01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Rb01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW635Mo01 Recombinant Interleukin 2 (IL2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW635Mo01 Monoclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IP.
PAW635Mo01 Polyclonal Antibody to Interleukin 2 (IL2) WB; IHC; ICC; IF.
Assay Kits CLW635Mo01 CLIA Kit for Interleukin 2 (IL2) CLIA assay for Antigen Detection
ELW635Mo01 ELISA Kit for Interleukin 2 (IL2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning of interleukin 2 mRNAs from human tonsils."
Biochem. Biophys. Res. Commun. 115:1040-1047(1983) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of a cloned cDNA for human interleukin-2."
Nature 302:305-310(1983) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of human interleukin 2 cDNA and its expression in E. coli."
Nucleic Acids Res. 11:4307-4323(1983) [PubMed] [Europe PMC] [Abstract]

"Structure of the human interleukin 2 gene."
Proc. Natl. Acad. Sci. U.S.A. 80:7437-7441(1983) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus."
Nucleic Acids Res. 12:5005-5013(1984) [PubMed] [Europe PMC] [Abstract]

"T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells."
Proc. Natl. Acad. Sci. U.S.A. 81:1634-1638(1984) [PubMed] [Europe PMC] [Abstract]

"Interleukin-2 transcripts in human and rodent brains: possible expression by astrocytes."
J. Neurochem. 64:1928-1936(1995) [PubMed] [Europe PMC] [Abstract]

"Sequence of interleukin-2 isolated from human placental poly A+ RNA: possible role in maintenance of fetal allograft."
Mol. Reprod. Dev. 43:180-186(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Organization of the DNA regions flanking the human interleukin 2 gene."
Biomed. Res. 6:197-205(1985)

"Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells."
Mol. Cell. Biol. 6:3042-3049(1986) [PubMed] [Europe PMC] [Abstract]

"Structure-activity relationships of recombinant human interleukin 2."
Biochemistry 27:6883-6892(1988) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence and post-translational modification of human interleukin 2."
Proc. Natl. Acad. Sci. U.S.A. 81:6486-6490(1984) [PubMed] [Europe PMC] [Abstract]

"Expression of human interleukin-2 in recombinant baby hamster kidney, Ltk-, and Chinese hamster ovary cells. Structure of O-linked carbohydrate chains and their location within the polypeptide."
J. Biol. Chem. 264:17368-17373(1989) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional structure of interleukin-2."
Science 238:1707-1709(1987) [PubMed] [Europe PMC] [Abstract]

"Unraveling the structure of IL-2."
Science 257:410-412(1992) [PubMed] [Europe PMC] [Abstract]

Science 257:412-413(1992)

"Secondary structure of human interleukin 2 from 3D heteronuclear NMR experiments."
Biochemistry 31:7741-7744(1992) [PubMed] [Europe PMC] [Abstract]

"The interleukin-2 and interleukin-4 receptors studied by molecular modelling."
Structure 2:839-851(1994) [PubMed] [Europe PMC] [Abstract]

"Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."
Science 310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."
Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]