Leptin (LEP)
OB; OBS; Obesity Homolog; Obesity Factor; Obese Protein
Leptin is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. Leptin is a 16-kD protein that plays a critical role in the regulation of body weight by inhibiting food intake and stimulating energy expenditure. Defects in leptin production cause severe hereditary obesity in rodents and humans. In addition to its effects on body weight, leptin has a variety of other functions, including the regulation of hematopoiesis, angiogenesis, wound healing, and the immune and inflammatory response. Leptin acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family, which is found in many tissues in several alternatively spliced forms. The LEP gene is the human homolog of the gene (ob) mutant in the mouse 'obese' phenotype.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Hu01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Hu01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Hu01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Hu01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Hu01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Mu01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Mu01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Mu01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Mu01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Mu01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Ra01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Ra01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Ra01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Ra01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Ra01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Ca01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Ca01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Ca01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Ca01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Ca01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Po01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Po01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Po01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Po01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Po01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Bo01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Bo01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Bo01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Bo01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Bo01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Rb01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Rb01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Rb01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Rb01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Rb01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW626Mo01 | Recombinant Leptin (LEP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW626Mo01 | Monoclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IP. |
| PAW626Mo01 | Polyclonal Antibody to Leptin (LEP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW626Mo01 | CLIA Kit for Leptin (LEP) | CLIA assay for Antigen Detection |
| ELW626Mo01 | ELISA Kit for Leptin (LEP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Positional cloning of the mouse obese gene and its human homologue."
Nature 372:425-432(1994) [PubMed] [Europe PMC] [Abstract]
Erratum
Nature 374:479-479(1995)
"Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue."
Diabetes 44:855-858(1995) [PubMed] [Europe PMC] [Abstract]
"Genomic structure and promoter analysis of the human obese gene."
J. Biol. Chem. 271:3971-3974(1996) [PubMed] [Europe PMC] [Abstract]
"Structural organization and chromosomal assignment of the human obese gene."
J. Biol. Chem. 270:27728-27733(1995) [PubMed] [Europe PMC] [Abstract]
"Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity."
Diabetes 45:675-678(1996) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily."
J. Biol. Chem. 274:22729-22738(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
J. Biol. Chem. 274:28058-28058(1999)
"Leptin is a four-helix bundle: secondary structure by NMR."
FEBS Lett. 407:239-242(1997) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the obese protein leptin-E100."
Nature 387:206-209(1997) [PubMed] [Europe PMC] [Abstract]
"A novel polymorphism in the leptin gene."
Hum. Mutat. 12:220-220(1998)
"A leptin missense mutation associated with hypogonadism and morbid obesity."
Nat. Genet. 18:213-215(1998) [PubMed] [Europe PMC] [Abstract]