Caspase 11 (CASP11)
SRSF2IP; SFRS2IP; SIP1; SRRP129; Cysteinyl Aspartate Specific Proteinases 11; Apoptosis-Related Cysteine Peptidase 11; Splicing Factor,Arginine/Serine-Rich 2,Interacting
This enzyme is a member of a family of evolutionarily conserved cysteine protease proteins known as caspases. Many of these enzymes are part of a proteolytic cascade that plays a central role in cell death by apoptosis. Caspase-11 has been isolated and characterized as ICH-3 [ICE and CED3 homolog-3]. Caspase-11 gene expression in response to bacterial lipopolysaccharides and IFN-gamma requires NF-kappa-B and the signal transducer STAT1 .
By performing a yeast 2-hybrid assay to identify proteins that interact with CTD, Tanner et al. (1997) isolated partial cDNAs encoding SIP1, which they called CTD-associated SR protein 11 (CASP11) or SR-related protein of 129 kD (SRrp129). Northern blot analysis detected expression of the approximately 6-kb SRrp129 mRNA in all tissues tested.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Hu01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Hu01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Hu01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Hu01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Hu01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Mu01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Mu01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Mu01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Mu01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Mu01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Ra01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Ra01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Ra01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Ra01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Ra01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Ca01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Ca01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Ca01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Ca01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Ca01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Po01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Po01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Po01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Po01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Po01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Bo01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Bo01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Bo01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Bo01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Bo01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Rb01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Rb01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Rb01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Rb01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Rb01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW616Mo01 | Recombinant Caspase 11 (CASP11) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW616Mo01 | Monoclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IP. |
| PAW616Mo01 | Polyclonal Antibody to Caspase 11 (CASP11) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW616Mo01 | CLIA Kit for Caspase 11 (CASP11) | CLIA assay for Antigen Detection |
| ELW616Mo01 | ELISA Kit for Caspase 11 (CASP11) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain."
Biol. Chem. 378:565-571(1997) [PubMed] [Europe PMC] [Abstract]
"Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing."
Mol. Cell. Biol. 18:676-684(1998) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
Int. J. Cancer 83:456-464(1999) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]