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Matrix Metalloproteinase 1 (MMP1)

CLGN; CLG1; Collagenase; Interstitial Collagenase; Vertebrate Collagenase; Fibroblast Collagenase

MMP-1 is produced by fibroblasts, chondrocytes, macrophages, endothelial cells, and osteoblasts. It is induced by the pro-inflammatory cytokines IL-1 and TNF-α, various growth factors such as EGF, PDGF, FGF basic, and Oncostatin M, chemical agents such as cAMP and phorbol esters and events occurring at the cell surface such as cell fusion and phagocytosis. MMP-1 plays a significant role in the degradation of different types of collagen in extracellular matrix remodeling. It is implicated in a variety of processes involving collagen degradation such as emphysema, atherosclerosis, rheumatoid and osteoarthritis, periodontal and respiratory disease, angiogenesis and tumorigenesis, tissue remodeling and wound healing, and inflammatory bowel disease.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Hu01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Hu01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Hu01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Hu01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Hu01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Mu01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Mu01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Mu01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Mu01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Mu01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Ra01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Ra01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Ra01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Ra01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Ra01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Ca01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Ca01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Ca01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Ca01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Ca01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Po01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Po01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Po01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Po01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Po01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Bo01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Bo01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Bo01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Bo01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Bo01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Rb01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Rb01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Rb01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Rb01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Rb01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW613Mo01 Recombinant Matrix Metalloproteinase 1 (MMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW613Mo01 Monoclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IP.
PAW613Mo01 Polyclonal Antibody to Matrix Metalloproteinase 1 (MMP1) WB; IHC; ICC; IF.
Assay Kits CLW613Mo01 CLIA Kit for Matrix Metalloproteinase 1 (MMP1) CLIA assay for Antigen Detection
ELW613Mo01 ELISA Kit for Matrix Metalloproteinase 1 (MMP1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and characterization of human tumor cell interstitial collagenase."
Cancer Res. 50:5431-5437(1990) [PubMed] [Europe PMC] [Abstract]

"Comparison of human stromelysin and collagenase by cloning and sequence analysis."
Biochem. J. 240:913-916(1986) [PubMed] [Europe PMC] [Abstract]

"Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein."
J. Biol. Chem. 261:6600-6605(1986) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region."
Mol. Cell. Biol. 7:2256-2266(1987) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA."
J. Clin. Invest. 79:542-546(1987) [PubMed] [Europe PMC] [Abstract]

"Fragments of human fibroblast collagenase. Purification and characterization."
Biochem. J. 263:201-206(1989) [PubMed] [Europe PMC] [Abstract]

"Human fibroblast collagenase contains an amino acid sequence homologous to the zinc-binding site of Serratia protease."
J. Biol. Chem. 262:5943-5943(1987) [PubMed] [Europe PMC] [Abstract]

"Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity."
J. Clin. Invest. 87:2258-2265(1991) [PubMed] [Europe PMC] [Abstract]

"N-glycan structures of matrix metalloproteinase-1 derived from human fibroblasts and from HT-1080 fibrosarcoma cells."
Eur. J. Biochem. 259:829-840(1999) [PubMed] [Europe PMC] [Abstract]

"Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanism."
FASEB J. 20:1736-1738(2006) [PubMed] [Europe PMC] [Abstract]

"A secreted tyrosine kinase acts in the extracellular environment."
Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor."
Nat. Struct. Biol. 1:106-110(1994) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself."
Biochemistry 33:8207-8217(1994) [PubMed] [Europe PMC] [Abstract]

"Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor."
Science 263:375-377(1994) [PubMed] [Europe PMC] [Abstract]

"1.56-A structure of mature truncated human fibroblast collagenase."
Proteins 19:98-109(1994) [PubMed] [Europe PMC] [Abstract]

"High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR."
Biochemistry 37:1495-1504(1998) [PubMed] [Europe PMC] [Abstract]