Osteoprotegerin (OPG)
TNFRSF11B; TNFRSF11-B; OCIF; OPG; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b; Osteoclastogenesis Inhibitory Factor
Osteoprotegerin (OPG) is a cytokine, which can inhibit the production of osteoclasts. It is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a basic glycoprotein comprising 401 amino acid residues arranged into 7 structural domains. It is found as either a 60 kDa monomer or 120 kDa dimer linked by disulfide bonds.Osteoprotegerin inhibits the differentiation of osteoclast precursors into osteoclasts and also regulates the resorption of osteoclasts in vitro and in vivo. Osteoprotegerin is a RANK homolog, and works by binding to RANKL on osteoblast/stromal cells, thus blocking the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Hu01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Hu01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Hu01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Hu01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Hu01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Mu01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Mu01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Mu01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Mu01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Mu01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Ra01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Ra01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Ra01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Ra01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Ra01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Ca01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Ca01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Ca01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Ca01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Ca01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Po01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Po01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Po01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Po01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Po01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Bo01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Bo01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Bo01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Bo01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Bo01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Rb01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Rb01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Rb01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Rb01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Rb01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW602Mo01 | Recombinant Osteoprotegerin (OPG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW602Mo01 | Monoclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IP. |
| PAW602Mo01 | Polyclonal Antibody to Osteoprotegerin (OPG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW602Mo01 | CLIA Kit for Osteoprotegerin (OPG) | CLIA assay for Antigen Detection |
| ELW602Mo01 | ELISA Kit for Osteoprotegerin (OPG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density."
Cell 89:309-319(1997) [PubMed] [Europe PMC] [Abstract]
"Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro."
Endocrinology 139:1329-1337(1998) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor."
Eur. J. Biochem. 254:685-691(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor."
Biochem. Biophys. Res. Commun. 245:382-387(1998) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of a novel mutated osteoprogerin/osteoclastogenesis inhibitory factor gene."
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 31:680-684(1999) [PubMed] [Europe PMC] [Abstract]
"Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis."
Biochem. Biophys. Res. Commun. 234:137-142(1997) [PubMed] [Europe PMC] [Abstract]
"Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL."
J. Biol. Chem. 273:14363-14367(1998) [PubMed] [Europe PMC] [Abstract]
"Characterization of structural domains of human osteoclastogenesis inhibitory factor."
J. Biol. Chem. 273:5117-5123(1998) [PubMed] [Europe PMC] [Abstract]
"Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases."
Cancer 92:460-470(2001) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."
J. Immunol. 189:245-252(2012) [PubMed] [Europe PMC] [Abstract]
"A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype."
Hum. Mol. Genet. 11:2119-2127(2002) [PubMed] [Europe PMC] [Abstract]