Stem Cell Factor (SCF)
KITLG; MGF; SF; KL1; Kitl; FPH2; Kit-Ligand; Steel Factor; Mast Cell Growth Factor; Steel factor; Familial Progressive Hyperpigmentation 2
Stem cell factor (SCF;MGF) is a cytokine which binds CD117 (c-Kit). SCF is also known as "steel factor" or "c-kit ligand". SCF exists in two forms, cell surface bound SCF and soluble (or free) SCF. Soluble SCF is produced by the cleavage of surface bound SCF by metalloproteases.SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E(burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid). SCF, along with bFGF (basic fibroblast growth factor) and LIF (leukemia inhibitory factor), prevents spontaneous differentiation of primitive embryonic stem cells in cell culture.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Hu01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Hu01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Hu01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Hu01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Hu01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Mu01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Mu01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Mu01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Mu01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Mu01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Ra01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Ra01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Ra01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Ra01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Ra01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Ca01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Ca01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Ca01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Ca01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Ca01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Po01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Po01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Po01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Po01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Po01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Bo01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Bo01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Bo01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Bo01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Bo01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Rb01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Rb01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Rb01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Rb01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Rb01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPW593Mo01 | Recombinant Stem Cell Factor (SCF) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAW593Mo01 | Monoclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IP. |
PAW593Mo01 | Polyclonal Antibody to Stem Cell Factor (SCF) | WB; IHC; ICC; IF. | |
Assay Kits | CLW593Mo01 | CLIA Kit for Stem Cell Factor (SCF) | CLIA assay for Antigen Detection |
ELW593Mo01 | ELISA Kit for Stem Cell Factor (SCF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Primary structure and functional expression of rat and human stem cell factor DNAs."
Cell 63:203-211(1990) [PubMed] [Europe PMC] [Abstract]
"Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24."
Cell Growth Differ. 2:373-378(1991) [PubMed] [Europe PMC] [Abstract]
"Parathyroid hormone-regulated production of stem cell factor in human osteoblasts and osteoblast-like cells."
Biochem. Biophys. Res. Commun. 255:778-784(1999) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells."
Arch. Biochem. Biophys. 298:150-158(1992) [PubMed] [Europe PMC] [Abstract]
"Expression of two types of kit ligand mRNAs in human tumor cells."
Int. J. Hematol. 55:301-304(1992) [PubMed] [Europe PMC] [Abstract]
"Stem cell factor/c-kit system in spermatogenesis."
Hum. Reprod. Update 5:535-545(1999) [PubMed] [Europe PMC] [Abstract]
"Signal transduction via the stem cell factor receptor/c-Kit."
Cell. Mol. Life Sci. 61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
"Normal and oncogenic forms of the receptor tyrosine kinase kit."
Stem Cells 23:16-43(2005) [PubMed] [Europe PMC] [Abstract]
"Genetic determinants of hair, eye and skin pigmentation in Europeans."
Nat. Genet. 39:1443-1452(2007) [PubMed] [Europe PMC] [Abstract]
"A molecular basis for classic blond hair color in Europeans."
Nat. Genet. 46:748-752(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of the active core of human stem cell factor and analysis of binding to its receptor kit."
EMBO J. 19:3192-3203(2000) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation."
Proc. Natl. Acad. Sci. U.S.A. 97:7732-7737(2000) [PubMed] [Europe PMC] [Abstract]
"Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor."
Cell 130:323-334(2007) [PubMed] [Europe PMC] [Abstract]
"Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation."
Am. J. Hum. Genet. 84:672-677(2009) [PubMed] [Europe PMC] [Abstract]