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Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1)

JTK14; Tyrosine Kinase With Immunoglobulin And Epidermal Growth Factor Homology Domains 1; Tyrosine-protein kinase receptor Tie-1

Tie1 is a cell surface protein expressed exclusively in endothelial cells. Tie1 upregulates the cell adhesion molecules VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by Tie1 expression. Tie1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. the combinatorial function of angiopoietin-1 and the orphan receptor TIE1 is critical for the development of the right-hand side venous system but is dispensable for the left-hand side venous system. This finding revealed the existence of a distinct genetic program for the establishment of the right-hand side and left-hand side vascular networks well before the network asymmetry becomes morphologically discernible.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Hu01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Hu01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Hu01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Hu01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Hu01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Mu01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Mu01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Mu01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Mu01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Mu01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Ra01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Ra01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Ra01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Ra01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Ra01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Ca01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Ca01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Ca01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Ca01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Ca01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Po01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Po01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Po01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Po01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Po01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Bo01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Bo01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Bo01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Bo01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Bo01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Rb01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Rb01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Rb01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Rb01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Rb01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPW588Mo01 Recombinant Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAW588Mo01 Monoclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IP.
PAW588Mo01 Polyclonal Antibody to Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) WB; IHC; ICC; IF.
Assay Kits CLW588Mo01 CLIA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) CLIA assay for Antigen Detection
ELW588Mo01 ELISA Kit for Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains Protein 1 (Tie1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains."
Mol. Cell. Biol. 12:1698-1707(1992) [PubMed] [Europe PMC] [Abstract]

"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Arthritis Res. Ther. 10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2."
J. Cell Biol. 169:239-243(2005) [PubMed] [Europe PMC] [Abstract]

"Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands."
Mol. Cell 37:643-655(2010) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]