Tissue Inhibitors Of Metalloproteinase 3 (TIMP3)
SFD; TIMP Metallopeptidase Inhibitor 3; Metallopeptidase Inhibitor 3; Sorsby Fundus Dystrophy; Pseudoinflammatory
TIMP3, The cDNAs contained a 591-bp open reading frame encoding 9 amino acid residues of the signal peptide and 188 residues of the mature TIMP3 polypeptide. Both the nucleotide sequence and the deduced translation product of the TIMP3 cDNA had a high degree of similarity to the TIMP1 and TIMP2 gene products, including 12 conserved cysteinyl residues at the same relative positions. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. Wilde et al. (1994) cloned and sequenced TIMP3 from phorbol ester-differentiated cells stimulated with bacterial lipopolysaccharide. The open reading frame encoded a 211-amino acid precursor, including a 23-residue secretion signal. The mature polypeptide had a calculated molecular weight of 21.6 kD.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Hu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Hu01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Hu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Hu01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Hu01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Mu01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Mu01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Mu01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Mu01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Mu01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Ra01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Ra01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Ra01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Ra01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Ra01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Ca01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Ca01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Ca01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Ca01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Ca01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Po01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Po01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Po01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Po01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Po01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Bo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Bo01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Bo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Bo01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Bo01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Rb01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Rb01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Rb01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Rb01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Rb01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW585Mo01 | Recombinant Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW585Mo01 | Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IP. |
| PAW585Mo01 | Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW585Mo01 | CLIA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | CLIA assay for Antigen Detection |
| ELW585Mo01 | ELISA Kit for Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family."
Cancer Res. 54:2091-2094(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of human tissue inhibitor of metalloproteinases-3."
DNA Cell Biol. 13:711-718(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family."
Gene 141:293-297(1994) [PubMed] [Europe PMC] [Abstract]
"A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence."
J. Biol. Chem. 269:18953-18960(1994) [PubMed] [Europe PMC] [Abstract]
"Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3)."
Genome Res. 5:483-487(1995) [PubMed] [Europe PMC] [Abstract]
"TIMP-3 is expressed in the human retinal pigment epithelium."
Biochem. Biophys. Res. Commun. 226:467-474(1996) [PubMed] [Europe PMC] [Abstract]
"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22."
Genomics 19:86-90(1994) [PubMed] [Europe PMC] [Abstract]
"Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix."
Matrix Biol. 14:479-488(1995) [PubMed] [Europe PMC] [Abstract]
"Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3."
Gene 170:287-288(1996) [PubMed] [Europe PMC] [Abstract]
"Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations."
J. Biol. Chem. 279:30469-30473(2004) [PubMed] [Europe PMC] [Abstract]
"Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex."
J. Mol. Biol. 381:1307-1319(2008) [PubMed] [Europe PMC] [Abstract]
"Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy."
Nat. Genet. 8:352-356(1994) [PubMed] [Europe PMC] [Abstract]
"A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features."
Hum. Mol. Genet. 4:2415-2416(1995) [PubMed] [Europe PMC] [Abstract]
"Night blindness in Sorsby's fundus dystrophy reversed by vitamin A."
Nat. Genet. 11:27-32(1995) [PubMed] [Europe PMC] [Abstract]
"A second independent Tyr168Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy."
J. Med. Genet. 33:233-236(1996) [PubMed] [Europe PMC] [Abstract]
"Autosomal recessive Sorsby fundus dystrophy revisited: molecular evidence for dominant inheritance."
Am. J. Hum. Genet. 60:57-62(1997) [PubMed] [Europe PMC] [Abstract]