Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL)
CD253; TNFSF10; APO2L; Apo2-L; TL2; TRAIL; Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand
TRAIL is a recently identified member of the TNF gene superfamily. Five different receptors have been identified for TRAIL. Two receptors, DR4 and DR5, are transmembrane proteins containing death domain similar to FAS and other TNF family receptors. Two other receptors, DcR1 and DcR2, act like decoy proteins for TRAIL binding because they lack the death domain. TRAIL can also bind, though weakly, to osteoprotegrin (OPG), a soluble receptor, which plays a role in osteoclastogenesis. TRAIL induces apoptosis in various tumor cell lines, whereas most primary cells seem to be resistant. TRAIL-mediated apoptosis occurs following its binding to DR4 or DR5 receptors. The mechanism of apoptosis involves activation of caspase-8 and subsequent activation of effector caspases.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Hu01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Hu01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Hu01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Hu01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Hu01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Mu01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Mu01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Mu01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Mu01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Mu01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Ra01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Ra01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Ra01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Ra01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Ra01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Ca01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Ca01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Ca01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Ca01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Ca01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Po01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Po01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Po01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Po01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Po01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Bo01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Bo01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Bo01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Bo01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Bo01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Rb01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Rb01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Rb01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Rb01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Rb01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW577Mo01 | Recombinant Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW577Mo01 | Monoclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IP. |
| PAW577Mo01 | Polyclonal Antibody to Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW577Mo01 | CLIA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | CLIA assay for Antigen Detection |
| ELW577Mo01 | ELISA Kit for Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Immunity 3:673-682(1995) [PubMed] [Europe PMC] [Abstract]
"Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family."
J. Biol. Chem. 271:12687-12690(1996) [PubMed] [Europe PMC] [Abstract]
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J. Biol. Chem. 286:35742-35754(2011) [PubMed] [Europe PMC] [Abstract]
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A secreted tyrosine kinase acts in the extracellular environment."
Cell 158:1033-1044(2014) [PubMed] [Europe PMC] [Abstract]
"Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5."
Mol. Cell 4:563-571(1999) [PubMed] [Europe PMC] [Abstract]
"Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation."
Nat. Struct. Biol. 6:1048-1053(1999) [PubMed] [Europe PMC] [Abstract]
"2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity."
Immunity 11:253-261(1999) [PubMed] [Europe PMC] [Abstract]