Intercellular Adhesion Molecule 5 (ICAM5)

TLCN; TLN; Telencephalin

SPN	W574
HGNC	5348
MGI	109430
PubMed	11026442
RGD	1305039
UniProt	Q9UMF0
Wiki	ICAM5

Intercellular adhesion molecule 5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.The 924-amino acid polypeptide comprises an N-terminal signal peptide, an extracellular region with 9 Ig-like domains, a single transmembrane region, and a C-terminal cytoplasmic tail.

Reference

"cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1."
J. Biol. Chem. 272:1156-1163(1997) [PubMed] [Europe PMC] [Abstract]

"Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2."
Genomics 54:328-330(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

"An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5."
Mol. Cell 31:432-437(2008) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]