Vascular Endothelial Growth Factor C (VEGFC)
VEGF-C; Flt4-L; VRPL; Vascular Endothelial Growth Factor-Related Protein
VEGF-C has been shown to exhibit angiogenic and lymphangiogenic actions. The VEGF family of growth factors and receptors is involved in the development and growth of the vascular endothelial system. Two of its family members, VEGF-C and VEGF-D, regulate the lymphatic endothelial cells via their receptor VEGFR, thus acting as mitogens for these cells. VEGF-C expression is associated with hematological malignancies. Like VEGF it acts as survival factor on leukemia. Together with the expression of their receptors, VEGF and VEGF-C result in the generation of autocrine loops that may support cancer cell survival and proliferation. Further VEGF-C expression has been shown in gastrointestinal tract malignancies where it correlates with lymphatic invasion, lymphnode metastasis and reduced survival.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Hu01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Hu01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Hu01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Hu01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Hu01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Mu01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Mu01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Mu01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Mu01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Mu01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Ra01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Ra01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Ra01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Ra01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Ra01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Ca01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Ca01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Ca01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Ca01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Ca01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Po01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Po01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Po01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Po01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Po01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Bo01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Bo01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Bo01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Bo01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Bo01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Rb01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Rb01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Rb01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Rb01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Rb01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW571Mo01 | Recombinant Vascular Endothelial Growth Factor C (VEGFC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW571Mo01 | Monoclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IP. |
| PAW571Mo01 | Polyclonal Antibody to Vascular Endothelial Growth Factor C (VEGFC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW571Mo01 | CLIA Kit for Vascular Endothelial Growth Factor C (VEGFC) | CLIA assay for Antigen Detection |
| ELW571Mo01 | ELISA Kit for Vascular Endothelial Growth Factor C (VEGFC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases."
EMBO J. 15:290-298(1996) [PubMed] [Europe PMC] [Abstract]
Erratum
EMBO J. 15:1751-1751(1996) [PubMed] [Europe PMC] [Abstract]
"Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4."
Proc. Natl. Acad. Sci. U.S.A. 93:1988-1992(1996) [PubMed] [Europe PMC] [Abstract]
"Characterization of murine Flt4 ligand/VEGF-C."
Oncogene 15:613-618(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Proteolytic processing regulates receptor specificity and activity of VEGF-C."
EMBO J. 16:3898-3911(1997) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema."
Circ. Res. 112:956-960(2013) [PubMed] [Europe PMC] [Abstract]
"A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease."
J. Med. Genet. 51:475-478(2014) [PubMed] [Europe PMC] [Abstract]
"Structural determinants of growth factor binding and specificity by VEGF receptor 2."
Proc. Natl. Acad. Sci. U.S.A. 107:2425-2430(2010) [PubMed] [Europe PMC] [Abstract]