Pepsinogen A (PGA)
PGA5; PG-A; Pepsinogen 5 Group I; Pepsinogen-5; Pepsin A-5
Pepsinogen A is secreted exclusively by the chief cells of the gastric corpus. The levels of Pepsinogen I correlate directly with the active number of chief cells in this area. In cases of severe atrophic gastritis of the corpus region, the chief cells will be destroyed and the levels of Pepsinogen I will fall dramatically.Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. It consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41-amino acid segment from the amino end. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Samloff and Townes (1970) showed that the pepsinogen-5 derived from the stomach and excreted in the urine is absent in some persons. Family and population data supported the view that absence of PG-5 is recessive.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Hu01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Hu01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Hu01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Hu01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Hu01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Mu01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Mu01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Mu01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Mu01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Mu01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Ra01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Ra01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Ra01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Ra01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Ra01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Ca01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Ca01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Ca01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Ca01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Ca01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Po01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Po01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Po01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Po01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Po01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Bo01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Bo01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Bo01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Bo01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Bo01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Rb01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Rb01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Rb01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Rb01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Rb01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW558Mo01 | Recombinant Pepsinogen A (PGA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW558Mo01 | Monoclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IP. |
| PAW558Mo01 | Polyclonal Antibody to Pepsinogen A (PGA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW558Mo01 | CLIA Kit for Pepsinogen A (PGA) | CLIA assay for Antigen Detection |
| ELW558Mo01 | ELISA Kit for Pepsinogen A (PGA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family."
Genomics 4:232-239(1989) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences."
J. Biochem. 98:483-492(1985) [PubMed] [Europe PMC] [Abstract]
"A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins."
J. Biochem. 106:920-927(1989) [PubMed] [Europe PMC] [Abstract]
"Activation of human pepsinogens."
FEBS Lett. 241:69-72(1988) [PubMed] [Europe PMC] [Abstract]
"Carboxyl-terminal sequence of human gastricsin and pepsin."
J. Biol. Chem. 245:2189-2193(1970) [PubMed] [Europe PMC] [Abstract]
"Primary structure of human pepsinogen gene."
J. Biol. Chem. 258:5306-5311(1983) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human pepsin and its complex with pepstatin."
Protein Sci. 4:960-972(1995) [PubMed] [Europe PMC] [Abstract]