Platelet Factor 4 (PF4)
CXCL4; SCYB4; Chemokine C-X-C-Motif Ligand 4; Oncostatin-A; Iroplact
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family. This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.PF4 is chemotactic for neutrophils, fibroblasts and monocytes, and interacts with a splice variant of the chemokine receptor CXCR3, known as CXCR3B. PF4 is the antigen in heparin-induced thrombocytopenia, an idiosyncratic autoimmune reaction to the administration of the anticoagulant heparin. PF4 autoantibodies have also been found in patients with thrombosis and features resembling HIT but no prior administration of heparin.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Hu01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Hu01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Hu01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Hu01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Hu01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Mu01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Mu01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Mu01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Mu01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Mu01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Ra01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Ra01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Ra01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Ra01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Ra01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Ca01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Ca01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Ca01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Ca01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Ca01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Po01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Po01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Po01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Po01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Po01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Bo01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Bo01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Bo01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Bo01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Bo01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Rb01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Rb01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Rb01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Rb01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Rb01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPW553Mo01 | Recombinant Platelet Factor 4 (PF4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAW553Mo01 | Monoclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IP. |
| PAW553Mo01 | Polyclonal Antibody to Platelet Factor 4 (PF4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLW553Mo01 | CLIA Kit for Platelet Factor 4 (PF4) | CLIA assay for Antigen Detection |
| ELW553Mo01 | ELISA Kit for Platelet Factor 4 (PF4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line."
Blood 69:219-223(1987) [PubMed] [Europe PMC] [Abstract]
"Structural and functional comparison of the genes for human platelet factor 4 and PF4alt."
Blood 76:336-344(1990) [PubMed] [Europe PMC] [Abstract]
"Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."
Blood 98:610-617(2001) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation, crystallization, and primary amino acid sequence of human platelet factor 4."
J. Biol. Chem. 252:6276-6279(1977) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequence of human platelet factor 4."
Proc. Natl. Acad. Sci. U.S.A. 74:2256-2258(1977) [PubMed] [Europe PMC] [Abstract]
"Primary structure of human platelet factor 4."
Thromb. Res. 11:893-898(1977) [PubMed] [Europe PMC] [Abstract]
"Complete covalent structure of human platelet factor 4."
Thromb. Haemost. 42:1652-1660(1980) [PubMed] [Europe PMC] [Abstract]
"A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4."
Proc. Natl. Acad. Sci. U.S.A. 92:7799-7803(1995) [PubMed] [Europe PMC] [Abstract]
"Alternative C-terminal helix orientation alters chemokine function: Structure of the Anti-angiogenic Chemokine, CXCL4L1."
J. Biol. Chem. 288:13522-13533(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of recombinant human platelet factor 4."
Biochemistry 33:8361-8366(1994) [PubMed] [Europe PMC] [Abstract]
"NMR solution structure of the 32-kDa platelet factor 4 ELR-motif N-terminal chimera: a symmetric tetramer."
Biochemistry 34:11399-11409(1995) [PubMed] [Europe PMC] [Abstract]