Prokineticin Receptor 1 (PKR1)

PROKR1; PKR-1; GPR73; GPR-73a; ZAQ; PK-R1; G Protein-Coupled Receptor 73; G-protein coupled receptor ZAQ

SPN	W538
HGNC	4524
MGI	1929676
PubMed	21856786
RGD	708443
UniProt	Q8TCW9
Wiki	PROK1

The prokineticin receptor is a G-protein coupled receptor which binds the peptide hormone prokineticin. These receptors mediate gastrointestinal smooth muscle contraction and angiogenesis. There are two variants each encoded by a different gene. Prokineticin receptor 1 (also known as PKR1, or GPR73A), is encoded by the PROKR1 gene. GPR73A is a receptor for prokineticin 1. It is a member of the GPCR family and is coupled to the G(q) subclass of heteromeric G proteins. Activation of the receptor leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. GPR73A expression has been reported in adrenal, peripheral blood leukocytes, brain, colon, pancreas, prostate, rectum, salivary gland, small intestine, spleen, stomach, testis, and thyroid.

Reference

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Endocrinology 149:2877-2887(2008) [PubMed] [Europe PMC] [Abstract]